3086248-19-0
Chemical Structure
SMD-6346
- CAS. Nr.: 3086248-19-0
- Formula:C46H50ClF2N5O4
- Molecular Weight:810.37
InChIKey: MTXCYMPXKRNURN-UHFFFAOYSA-N
SMILES: O=C(C(C1=C(F)C=C(N(CC2)CCC32CCC(CN4CCC(C5=CC(N6C7=NC(C8=C6C=CC=C8Cl)=O)=C(C97CCCCC9)C=C5)CC4)CO3)C=C1F)CC%10)NC%10=O
Biological Activity: SMD-6346 is an orally active SMARCA2 PROTAC degrader with a DC50 of 3.3 nM. SMD-6346 induces SMARCA2 degradation and exhibits extremely low activity against SMARCA4. SMD-6346 inhibits the growth of SMARCA4-deficient cancer cells and suppresses tumor growth in mouse xenograft models. SMD-6346 can be used for the research of non-small cell lung cancer[1].
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SMD-6346 | SMD-6346 is an orally active SMARCA2 PROTAC degrader with a DC50 of 3.3 nM. SMD-6346 induces SMARCA2 degradation and exhibits extremely low activity against SMARCA4. SMD-6346 inhibits the growth of SMARCA4-deficient cancer cells and suppresses tumor growth in mouse xenograft models. SMD-6346 can be used for the research of non-small cell lung cancer. | |||||||||||||||||||||
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Keywords
