30868-30-5
Chemical Structure
Pyrazofurin
Synonym(s): Pirazofurin
- CAS No.: 30868-30-5
- Formula:C9H13N3O6
- Molecular Weight:259.22
IUPAC Name: 5-((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxy-1H-pyrazole-3-carboxamide
InChIKey: XESARGFCSKSFID-FLLFQEBCSA-N
SMILES: O=C(N)C1=NNC([C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=C1O
Biological Activity: Pyrazofurin is an antitumor pyrimidine nucleoside analogue and a orotate-phosphoribosyltransferase inhibitor. Pyrazofurin inhibits cell proliferation and intracellular DNA synthesis by inhibiting uridine 5'-phosphate synthase. Pyrazofurin is also an antibiotic with a broad spectrum of antiviral activity[1][2][3][4].
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Pyrazofurin | 99.00% | Pyrazofurin is an antitumor pyrimidine nucleoside analogue and a orotate-phosphoribosyltransferase inhibitor. Pyrazofurin inhibits cell proliferation and intracellular DNA synthesis by inhibiting uridine 5'-phosphate synthase. Pyrazofurin is also an antibiotic with a broad spectrum of antiviral activity. | ||||||||||||||||||||
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Similarity Score 1.00
HY-N14611Pyrazomycin Ⅱ -
Similarity Score 0.61
HY-114570Tiazofurin -
Similarity Score 0.61
HY-106685Selenazofurin -
Similarity Score 0.57
HY-102026Formycin A -
Similarity Score 0.57
HY-124210Formycin B -
Similarity Score 0.57
HY-1527475-β-D-Ribofuranosyl-2(1H)-pyridinone -
Similarity Score 0.55
HY-152297(1S)-1,4-Anhydro-1-C-(2,4-difluorophenyl)-D-ribitol -
Similarity Score 0.55
HY-152305(1S)-1,4-Anhydro-1-C-(2,4-difluoro-5-methylphenyl)-D-ribitol -
Similarity Score 0.54
HY-146344Antiviral agent 17 -
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References
- [1]. Ringer DP, et al. Alteration in de novo pyrimidine biosynthesis during uridine reversal of pyrazofurin-inhibited DNA synthesis. Neuropsychopharmacology. J Biochem Toxicol. 1991 Spring;6(1):19-27. [Content Brief]
- [2]. Peters GJ, et al. Antipyrimidine effects of five different pyrimidine de novo synthesis inhibitors in three head and neck cancer cell lines. Nucleosides Nucleotides Nucleic Acids. 2018;37(6):329-339. [Content Brief]
- [3]. Petrie CR 3rd, et al. Synthesis and biological activity of certain nucleoside and nucleotide derivatives of pyrazofurin. J Med Chem. 1986 Feb;29(2):268-78. [Content Brief]
- [4]. Canonico PG, et al. Antiviral efficacy of pyrazofurin against selected RNA viruses. Antiviral Res. 1982 Dec;2(6):331-7. [Content Brief]
