3088796-72-6
3088796-72-6
Chemical Structure
NLRP3-IN-79
- CAS No.: 3088796-72-6
- Formula:C23H28N4O2
- Molecular Weight:392.49
InChIKey: MEUNMHKINHIBPY-UHFFFAOYSA-N
SMILES: CCNC(N(CC1=CN=CC=C1)CC(NC2=C3C(CCC3)=CC4=C2CCC4)=O)=O
Biological Activity: NLRP3-IN-79 is an orally active NLRP3 inhibitor. NLRP3-IN-79 inhibits NLRP3 inflammasome with an IC50 of 10.69 nM. NLRP3-IN-79 blocks NLRP3 inflammasome assembly by directly binding to NLRP3 and disrupting the NEK7-NLRP3 interaction. NLRP3-IN-79 can be used for the study of NLRP3-driven diseases model, including systemic inflammation, peritonitis, and colitis[1].
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NLRP3-IN-79 | 99.10% | NLRP3-IN-79 is an orally active NLRP3 inhibitor. NLRP3-IN-79 inhibits NLRP3 inflammasome with an IC50 of 10.69 nM. NLRP3-IN-79 blocks NLRP3 inflammasome assembly by directly binding to NLRP3 and disrupting the NEK7-NLRP3 interaction. NLRP3-IN-79 can be used for the study of NLRP3-driven diseases model, including systemic inflammation, peritonitis, and colitis. | ||||||||||||||||||||
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References
Keywords
