3100242-36-9
Chemical Structure
FLC-8
- CAS No.: 3100242-36-9
- Formula:C24H19F3N6O3
- Molecular Weight:496.44
InChIKey: DCEKXISNDUDPSD-UHFFFAOYSA-N
SMILES: C=CC(NC1=C(C(F)(F)F)C=C(NC(NC2=CC=C(C3=C(C(N)=NO4)C4=NC(C)=C3)C=C2)=O)C=C1)=O
Biological Activity: FLC-8 is an orally active FLT3 inhibitor with IC50 values of 10.2 nM, 11.6 nM and 24.10 nM against human FLT3-WT, FLT3-G697R and FLT3-N676D, respectively. FLC-8 inhibits FLT3 autophosphorylation and downstream STAT5, AKT and ERK signaling pathways, and induces apoptosis in acute myeloid leukemia (AML) cells. FLC-8 exhibits potent antitumor activity in the MV4-11 xenograft model. FLC-8 can be used for the research of acute myeloid leukemia[1].
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FLC-8 | FLC-8 is an orally active FLT3 inhibitor with IC50 values of 10.2 nM, 11.6 nM and 24.10 nM against human FLT3-WT, FLT3-G697R and FLT3-N676D, respectively. FLC-8 inhibits FLT3 autophosphorylation and downstream STAT5, AKT and ERK signaling pathways, and induces apoptosis in acute myeloid leukemia (AML) cells. FLC-8 exhibits potent antitumor activity in the MV4-11 xenograft model. FLC-8 can be used for the research of acute myeloid leukemia. | |||||||||||||||||||||
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Keywords
