3106364-91-1
Chemical Structure
Bfl-1-IN-6 TFA
- CAS No.: 3106364-91-1
- Formula:C24H25ClF4N2O4
- Molecular Weight:516.92
IUPAC Name: N-(4-(((1R,3R)-3-aminocyclopentyl)oxy)-3-fluorophenyl)-N-((S)-1-(4-chlorophenyl)ethyl)acrylamide 2,2,2-trifluoroacetate
InChIKey: HJRLDGALXMTJAU-QULYPMOISA-N
SMILES: C(C(O)=O)(F)(F)F.N([C@@H](C)C1=CC=C(Cl)C=C1)(C(C=C)=O)C2=CC(F)=C(O[C@@H]3CC[C@@H](N)C3)C=C2
Biological Activity: Bfl-1-IN-6 TFA is an orally active BFL1 inhibitor with an IC50 of 19 nM. Bfl-1-IN-6 TFA selectively binds covalently to BFL1, stabilizes the protein and displaces BIM from BFL1, thereby inducing apoptosis activity. Bfl-1-IN-6 TFA stabilizes BFL1 protein, activates cleaved caspase 3, and exhibits antitumor activity in mouse models. Bfl-1-IN-6 TFA can be used for the research of hematological malignancies[1].
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Bfl-1-IN-6 TFA | Bfl-1-IN-6 TFA is an orally active BFL1 inhibitor with an IC50 of 19 nM. Bfl-1-IN-6 TFA selectively binds covalently to BFL1, stabilizes the protein and displaces BIM from BFL1, thereby inducing apoptosis activity. Bfl-1-IN-6 TFA stabilizes BFL1 protein, activates cleaved caspase 3, and exhibits antitumor activity in mouse models. Bfl-1-IN-6 TFA can be used for the research of hematological malignancies. | |||||||||||||||||||||
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Keywords
