3109600-48-5
Chemical Structure
TRAP-1
Synonym(s): XJZ-06-462
- CAS No.: 3109600-48-5
- Formula:C57H66ClF3N11O3PS
- Molecular Weight:1108.69
InChIKey: QTMDJBYODRXSEP-GGCSAXROSA-N
SMILES: CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(N4CCN(CC4)CC5CCN(CC5)C(CN6CCC(CC6)NC7=C8C(N(C(C#CCNC9=CC=C(C=C9)P(C)(C)=O)=C8)CC(F)(F)F)=CC=C7)=O)=O)C%10=NN=C(C)N2%10
Biological Activity: TRAP-1 (XJZ-06-462) is a transcriptional activator of p53 (TRAP) with JQ-1 carboxylic acid (HY-78695) as its target protein ligand. TRAP-1 forms a ternary complex with p53Y220C and BRD4, potently activates p53 transcription, and inhibits the growth and proliferation of tumor cells. TRAP-1 upregulates p21 and other p53 target genes in pancreatic cell lines carrying p53Y220C, and induces cellular senescence and apoptosis. TRAP-1 can be used in cancer research involving p53Y220C-carrying tumors[1].
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TRAP-1 | 99.69% | TRAP-1 (XJZ-06-462) is a transcriptional activator of p53 (TRAP) with JQ-1 carboxylic acid (HY-78695) as its target protein ligand. TRAP-1 forms a ternary complex with p53Y220C and BRD4, potently activates p53 transcription, and inhibits the growth and proliferation of tumor cells. TRAP-1 upregulates p21 and other p53 target genes in pancreatic cell lines carrying p53Y220C, and induces cellular senescence and apoptosis. TRAP-1 can be used in cancer research involving p53Y220C-carrying tumors. | ||||||||||||||||||||
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Keywords
