3115133-30-4
3115133-30-4
Chemical Structure
PI3Kα-IN-31
- CAS 番号: 3115133-30-4
- Formula:C29H19ClF5N5O4
- Molecular Weight:631.94
InChIKey: YKYRPZRIAQGZEW-UHFFFAOYSA-N
SMILES: O=C(C1=CC(NC(C2=CC(NC(C3=CC(F)=CC(C(F)(F)F)=C3)=O)=C4N2CC(NC4C5=CC(F)=CC=C5Cl)=O)=O)=CC=C1)N
Biological Activity: PI3Kα-IN-31 is an orally active and selective PI3Kα inhibitor. PI3Kα-IN-31 shows potent preference for mutant PI3Kα over wild-type PI3Kα. PI3Kα-IN-31 exerts antiproliferative effects in PI3Kα-mutant cancer cells. PI3Kα-IN-31 suppresses tumor growth in xenograft models. PI3Kα-IN-31 can be used for the research of breast cancer[1].
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PI3Kα-IN-31 | PI3Kα-IN-31 is an orally active and selective PI3Kα inhibitor. PI3Kα-IN-31 shows potent preference for mutant PI3Kα over wild-type PI3Kα. PI3Kα-IN-31 exerts antiproliferative effects in PI3Kα-mutant cancer cells. PI3Kα-IN-31 suppresses tumor growth in xenograft models. PI3Kα-IN-31 can be used for the research of breast cancer. | |||||||||||||||||||||
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References
Keywords
