3133307-16-8
Chemical Structure
PROTAC HDAC6 degrader 7
- CAS No.: 3133307-16-8
- Formula:C49H54N8O6
- Molecular Weight:851.00
InChIKey: CAOCLYVIWYIDKK-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(CN2C3=CC=CC=C3C=CC4=C2C=CC=C4OCCN5CCN(CC5)CC6CCN(C7=CC=C8C(C(N(C8=O)C9CCC(NC9=O)=O)=O)=C7)CC6)C=C1)NNCC
Biological Activity: PROTAC HDAC6 degrader 7 is an orally active, highly efficient, and selective PROTAC degrader targeting histone deacetylase 6 (HDAC6) (IC50 = 118 nM). PROTAC HDAC6 degrader 7 can eliminate both the catalytic and zinc-finger ubiquitin-binding domain. PROTAC HDAC6 degrader 7 inhibits NLRP3 inflammasome assembly and activation, as well as blocks NF-κB signaling, thereby reducing the transcription and release of key inflammatory factors. PROTAC HDAC6 degrader 7 can reduce the mRNA levels of NLRP3, pro-IL-1β, TNF-α, and IL-6. PROTAC HDAC6 degrader 7 can be used for the study of inflammatory bowel disease (IBD)[1].
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PROTAC HDAC6 degrader 7 | PROTAC HDAC6 degrader 7 is an orally active, highly efficient, and selective PROTAC degrader targeting histone deacetylase 6 (HDAC6) (IC50 = 118 nM). PROTAC HDAC6 degrader 7 can eliminate both the catalytic and zinc-finger ubiquitin-binding domain. PROTAC HDAC6 degrader 7 inhibits NLRP3 inflammasome assembly and activation, as well as blocks NF-κB signaling, thereby reducing the transcription and release of key inflammatory factors. PROTAC HDAC6 degrader 7 can reduce the mRNA levels of NLRP3, pro-IL-1β, TNF-α, and IL-6. PROTAC HDAC6 degrader 7 can be used for the study of inflammatory bowel disease (IBD). | |||||||||||||||||||||
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