3137103-02-4
Chemical Structure
SYC-2863
- CAS No.: 3137103-02-4
- Formula:C42H47N9O5
- Molecular Weight:757.88
InChIKey: BVGLEYBMIDCSSV-HJYWNDIWSA-N
SMILES: O=C1CCC(N2C(C(C=CC=C3NCCCCCCCCN4C(C=CC(C(NC5=CC(NC(CN6[C@@H](C)CCC6)=C7)=C7C=N5)=O)=C8)=C8C=N4)=C3C2=O)=O)C(N1)=O
Biological Activity: SYC-2863 is a CRBN-recruiting PROTAC degrader that selectively degrades ENL (MLLT1), with an ENL DC50 of 45 nM in MV4;11 cells. SYC-2863 inhibits the proliferation of MLL-rearranged leukemia and multiple myeloma cells. After degrading intracellular ENL, SYC-2863 dose-dependently downregulates the transcription levels of MYC and its downstream target genes, blocking the MYC-mediated malignant proliferation pathway. SYC-2863 can be used in studies related to MLL-rearranged leukemia and multiple myeloma[1].
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SYC-2863 | SYC-2863 is a CRBN-recruiting PROTAC degrader that selectively degrades ENL (MLLT1), with an ENL DC50 of 45 nM in MV4;11 cells. SYC-2863 inhibits the proliferation of MLL-rearranged leukemia and multiple myeloma cells. After degrading intracellular ENL, SYC-2863 dose-dependently downregulates the transcription levels of MYC and its downstream target genes, blocking the MYC-mediated malignant proliferation pathway. SYC-2863 can be used in studies related to MLL-rearranged leukemia and multiple myeloma. | |||||||||||||||||||||
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