3137514-33-8
3137514-33-8
Chemical Structure
BChE-IN-56
- CAS No.: 3137514-33-8
- Formula:C20H24N2O2
- Molecular Weight:324.42
InChIKey: KRYRABPRBOIAGW-SFHVURJKSA-N
SMILES: CC1=CC=CC=C1NC(OC[C@@H]2CN(CC3=CC=CC=C3)CC2)=O
Biological Activity: BChE-IN-56 is a blood-brain barrier-penetrant BChE inhibitor. BChE-IN-56 covalently carbamoylates the catalytic serine Ser198, producing pseudo-irreversible inhibition, with an IC50 of 18.2 nM and a Ki of 416 nM against hBChE. BChE-IN-56 improves cognitive performance in mouse models of cognitive impairment without inducing motor deficits. BChE-IN-56 can be used for research on Alzheimer's disease[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
BChE-IN-56 | BChE-IN-56 is a blood-brain barrier-penetrant BChE inhibitor. BChE-IN-56 covalently carbamoylates the catalytic serine Ser198, producing pseudo-irreversible inhibition, with an IC50 of 18.2 nM and a Ki of 416 nM against hBChE. BChE-IN-56 improves cognitive performance in mouse models of cognitive impairment without inducing motor deficits. BChE-IN-56 can be used for research on Alzheimer's disease. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
