31635-99-1
Chemical Structure
Mesoxalate sodium monohydrate
- CAS No.: 31635-99-1
- Formula:C3H2Na2O6
- Molecular Weight:180.02
IUPAC Name: sodium 2,2-dihydroxymalonate
InChIKey: HMBGDJCPFGQLIO-UHFFFAOYSA-L
SMILES: O=C([O-])C(O)(O)C([O-])=O.[Na+].[Na+]
Biological Activity: Mesoxalate sodium monohydrate is an orally active antidiabetic agent. Mesoxalate sodium monohydrate increases pancreatic insulin content. Mesoxalate sodium monohydrate reduces dietary hyperglycemia. Mesoxalate sodium monohydrate inhibits Epinephrine-induced hyperglycemia in rabbits and exacerbates Alloxan (HY-116823)-induced hypoglycemic convulsions. Mesoxalate sodium monohydrate exerts no antidiabetic effect in pancreatectomized dogs and fails to reduce the susceptibility of rabbits to Alloxan-induced diabetes. Mesoxalate sodium monohydrate can be used in diabetes-related research[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Mesoxalate sodium monohydrate | Mesoxalate sodium monohydrate is an orally active antidiabetic agent. Mesoxalate sodium monohydrate increases pancreatic insulin content. Mesoxalate sodium monohydrate reduces dietary hyperglycemia. Mesoxalate sodium monohydrate inhibits Epinephrine-induced hyperglycemia in rabbits and exacerbates Alloxan (HY-116823)-induced hypoglycemic convulsions. Mesoxalate sodium monohydrate exerts no antidiabetic effect in pancreatectomized dogs and fails to reduce the susceptibility of rabbits to Alloxan-induced diabetes. Mesoxalate sodium monohydrate can be used in diabetes-related research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Bernatchez JA, et al. Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase. The Journal of biological chemistry. 2015 Jan 16;290(3):1474-84. [Content Brief]
- [2]. Davis WR, et al. Inhibition of HIV-1 reverse transcriptase-catalyzed DNA strand transfer reactions by 4-chlorophenylhydrazone of mesoxalic acid. Biochemistry. 2000 Nov 21;39(46):14279-91. [Content Brief]
- [3]. TAKEUCHI S. Effect of mesoxalate on insulin content of pancreas. Endocrinol Jpn. 1958 Sep;5(3):177-84. [Content Brief]
- [4]. KOBAYASHI Y, et al. Mechanism of anti-diabetic activity of calcium mesoxalate[J]. The Japanese Journal of Pharmacology, 1955, 4(2): 103-110.
Keywords
