32452-17-8
Chemical Structure
Guanosine 3',5'-bisdiphosphate
Synonym(s): ppGpp
- CAS. Nr.: 32452-17-8
- Formula:C10H17N5O17P4
- Molecular Weight:603.16
IUPAC Name: (2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-hydroxy-2-(((hydroxy(phosphonooxy)phosphoryl)oxy)methyl)tetrahydrofuran-3-yl trihydrogen diphosphate
InChIKey: BUFLLCUFNHESEH-UUOKFMHZSA-N
SMILES: O=C1C(N=CN2[C@H]3[C@H](O)[C@H](OP(OP(O)(O)=O)(O)=O)[C@@H](COP(OP(O)(O)=O)(O)=O)O3)=C2N=C(N)N1
Biological Activity: Guanosine 3',5'-bisdiphosphate (ppGpp) is a guanosine derivative that inhibits guanylate kinase. Guanosine 3',5'-bisdiphosphate binds to the β' subunit of plastid-encoded bacterial-type RNA polymerase, inhibits the catalytic activity of guanylate kinase, and regulates chloroplast translation and GTP biosynthesis. Guanosine 3',5'-bisdiphosphate acts as a plant chloroplast signaling molecule and a global bacterial regulator, and plays a role in microbial persistence. Guanosine 3',5'-bisdiphosphate is applicable to biosynthesis-related research[1][2][3].
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Guanosine 3',5'-bisdiphosphate | Guanosine 3',5'-bisdiphosphate (ppGpp) is a guanosine derivative that inhibits guanylate kinase. Guanosine 3',5'-bisdiphosphate binds to the β' subunit of plastid-encoded bacterial-type RNA polymerase, inhibits the catalytic activity of guanylate kinase, and regulates chloroplast translation and GTP biosynthesis. Guanosine 3',5'-bisdiphosphate acts as a plant chloroplast signaling molecule and a global bacterial regulator, and plays a role in microbial persistence. Guanosine 3',5'-bisdiphosphate is applicable to biosynthesis-related research. | |||||||||||||||||||||
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References
- [1]. Yamburenko MV, et al. Abscisic acid affects transcription of chloroplast genes via protein phosphatase 2C-dependent activation of nuclear genes: repression by guanosine-3'-5'-bisdiphosphate and activation by sigma factor 5. The Plant journal : for cell and molecular biology. 2015 Jun;82(6):1030-1041. [Content Brief]
- [2]. Nomura Y, et al. Diversity in guanosine 3',5'-bisdiphosphate (ppGpp) sensitivity among guanylate kinases of bacteria and plants. The Journal of biological chemistry. 2014 May 30;289(22):15631-41. [Content Brief]
- [3]. Vogel U, et al. Effects of guanosine 3',5'-bisdiphosphate (ppGpp) on rate of transcription elongation in isoleucine-starved Escherichia coli. The Journal of biological chemistry. 1994 Jun 10;269(23):16236-41. [Content Brief]
