326850-30-0
Chemical Structure
Nitroparacetamol
Synonym(s): NCX-701
- CAS No.: 326850-30-0
- Formula:C12H14N2O6
- Molecular Weight:282.25
IUPAC Name: 4-acetamidophenyl 4-(nitrooxy)butanoate
InChIKey: XTMOQAKCOFLCRZ-UHFFFAOYSA-N
SMILES: O=C(CCCO[N+]([O-])=O)OC1=CC=C(C=C1)NC(C)=O
Biological Activity: Nitroparacetamol (NCX-701) is a nitric oxide (NO) donor-non-steroidal anti-inflammatory agent (NO-NSAID). Nitroparacetamol is formed by the ester linkage of Acetaminophen (HY-66005) and Nitrooxybutyroyl, aiming to combine the analgesic advantage of Acetaminophen with the organ-protective effect of nitric oxide, while expanding its anti-inflammatory activity. The analgesic spectrum of Nitroparacetamol is broader, and it is effective for painful pathological pain, and significantly reduces hepatotoxicity. Nitroparacetamol can reduce the expressions of IL-1β, TNF-α, COX-2, and iNOS.
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Nitroparacetamol | Nitroparacetamol (NCX-701) is a nitric oxide (NO) donor-non-steroidal anti-inflammatory agent (NO-NSAID). Nitroparacetamol is formed by the ester linkage of Acetaminophen (HY-66005) and Nitrooxybutyroyl, aiming to combine the analgesic advantage of Acetaminophen with the organ-protective effect of nitric oxide, while expanding its anti-inflammatory activity. The analgesic spectrum of Nitroparacetamol is broader, and it is effective for painful pathological pain, and significantly reduces hepatotoxicity. Nitroparacetamol can reduce the expressions of IL-1β, TNF-α, COX-2, and iNOS. | |||||||||||||||||||||
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