33386-08-2
33386-08-2
Chemical Structure
Buspirone hydrochloride
- CAS No.: 33386-08-2
- Formula:C21H32ClN5O2
- Molecular Weight:421.96
IUPAC Name: 8-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro[4.5]decane-7,9-dione hydrochloride
InChIKey: RICLFGYGYQXUFH-UHFFFAOYSA-N
SMILES: O=C(N(CCCCN1CCN(C2=NC=CC=N2)CC1)C(C3)=O)CC43CCCC4.[H]Cl
Biological Activity: Buspirone hydrochloride is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Buspirone hydrochloride | 99.99% | Buspirone hydrochloride is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research. | ||||||||||||||||||||
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Buspirone hydrochloride (Standard) | ≥98% | Buspirone (hydrochloride) (Standard) is the analytical standard of Buspirone (hydrochloride). This product is intended for research and analytical applications. Buspirone hydrochloride is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research. | ||||||||||||||||||||
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Buspirone-d8 hydrochloride | Buspirone-d8 (hydrochloride) is the deuterium labeled Buspirone hydrochloride. Buspirone hydrochloride is an anxiolytic psychotropic agent, is used to treat generalized anxiety disorder (GAD). | |||||||||||||||||||||
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Buspirone-d8 dihydrochloride | Buspirone-d8 dihydrochloride is the deuterium labeled Buspirone hydrochloride (HY-B1115). Buspirone hydrochloride is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research. | |||||||||||||||||||||
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BMY 28674 | BMY 28674 (6-Hydroxybuspirone) is the active metabolite of the anxiolytic buspirone (HY-B1115A) and is metabolized by CYP3A4.4. BMY 28674 binds to the serotonin (5-HT) receptor subtype 5-HT1A in the rat hippocampus and dorsal raphe (EC50s are 4 and 1 μM, respectively) and is an antagonist of dopamine D2, D3, and D4 receptors (IC50s are 3.1, 4.9, and 0.85 μM, respectively). BMY 28674 also inhibits organic cation transporter 1 (OCT1), OCT2, and OCT3 expressing human transporters in S2 proximal tubule cells in a concentration-dependent manner. | |||||||||||||||||||||
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(R)-6-Hydroxybuspirone | (R)-6-Hydroxybuspirone is a metabolite of the anxiolytic agent Buspirone (HY-B1115A). (R)-6-Hydroxybuspirone itself also has anxiolytic activity. | |||||||||||||||||||||
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BMS-442606 | BMS-442606, the S-enantiomer of 6-hydroxybuspirone (6OHB), is an orally active 5-HT1A partial agonist. BMS-442606 can be used for generalized anxiety disorder (GAD) research. | |||||||||||||||||||||
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Gepirone hydrochloride | 99.88% | Gepirone is a selective 5-HT1A agonist. Gepirone binds selectively to 5-HT1A receptor binding site. Gepirone acts as an antidepressant agent can be used for anxiety and major depressive disorder research. | ||||||||||||||||||||
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Gepirone (Standard) | ≥98% | Gepirone (Standard) is the analytical standard of Gepirone. This product is intended for research and analytical applications. Gepirone is a selective and affinitive 5-HT1A agonist. Gepirone binds selectively to 5-HT1A receptor binding site. Gepirone acts as an antidepressant agent can be used for anxiety and major depressive disorder research. | ||||||||||||||||||||
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Buspirone N-oxide | Buspirone N-oxide (Bu N-oxide) is a metabolite of Buspirone (HY-B1115A). Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research. | |||||||||||||||||||||
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Buspirone | 99.86% | Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research. | ||||||||||||||||||||
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5-Hydroxybuspirone | 5-Hydroxybuspirone is a metabolite of the anti-anxiety agent Buspirone (HY-B1115A). | |||||||||||||||||||||
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Buspirone impurity 2 | Buspirone impurity 2 (5-Chloro buspirone) is an impurity of Buspirone. | |||||||||||||||||||||
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Buspirone EP impurity J | Buspirone EP impurity J is an impurity of Buspirone. | |||||||||||||||||||||
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References
- [1]. Salimi A, et, al. Analysis of Toxicity Effects of Buspirone, Cetirizine and Olanzapine on Human Blood Lymphocytes: in Vitro Model. Curr Clin Pharmacol. 2018;13(2):120-127. [Content Brief]
- [2]. Kim JK, et, al. Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice. Sci Rep. 2021 Mar 17;11(1):6094. [Content Brief]
