Buspirone (hydrochloride)
Based on 3 publication(s) in Google Scholar
Buspirone hydrochloride is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.99%
- CAS 番号: 33386-08-2
- 分子式: C21H32ClN5O2
- 分子量:421.96
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Buspirone hydrochloride
More5-HT Receptor アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
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5-HT1A Receptor |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
41 nM
Compound: 1
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Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
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[PMID: 19147349] |
| HEK293 | IC50 |
1.7 μM
Compound: buspirone
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Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
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[PMID: 23241029] |
| HEK293 | IC50 |
12 μM
Compound: buspirone
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Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
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[PMID: 23241029] |
| HEK293 | IC50 |
46 μM
Compound: buspirone
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Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
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[PMID: 23241029] |
体外実験
Buspirone hydrochloride (0-400 μg/mL; 6 hours) has cytotoxic effect in Lymphocytes[1].
Buspirone hydrochloride (0-180 μg/mL; 0-3 hours; Lymphocytes) induces ROS formation, MMP collapse, lipid peroxidation, lysosomal damage and elevation of glutathione disulfide (GSSG)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Lymphocytes
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Concentration:0, 4, 20, 40, 200 and 400 µg/mL
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Incubation Time:6 hours
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Result:Decreased cell viability in a dose-dependent manner.
体内実験
Buspirone hydrochloride (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) restores IS-shifted β-diversity in the gut microbiota[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6N mice[2]
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Dosage:1 and 5 mg/kg
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Administration:Oral gavage and intraperitoneal injection; for 5 days
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Result:Reduced TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus and myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon.
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Animal Model:Male C57BL/6N mice[2]
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Dosage:1 and 5 mg/kg
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Administration:Oral gavage and intraperitoneal injection; for 5 days
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Result:Reduced the IS- or EC-induced gut Proteobacteria population.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 33386-08-2
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性状 Solid
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分子量 421.96
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分子式 C21H32ClN5O2
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Color White to off-white
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SMILES
O=C(N(CCCCN1CCN(C2=NC=CC=N2)CC1)C(C3)=O)CC43CCCC4.[H]Cl
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別名
ブスピロン塩酸塩
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Environ Sci Technol
Data-Driven Discovery of Unknown Precursors of N-Nitrosodimethylamine in Nontargeted Liquid Chromatography-High Resolution Mass Spectrometry Analysis. [Abstract]2026 Mar 3;60(8):6558-6568. PMID: 41714108 -
Clin Pharmacol Ther
Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter-Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™). [Abstract]2025 Jul 14. PMID: 40657937 -
Mol Pharmacol
2023 Nov;104(5):230-238. PMID: 37567783
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (118.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Salimi A, et, al. Analysis of Toxicity Effects of Buspirone, Cetirizine and Olanzapine on Human Blood Lymphocytes: in Vitro Model. Curr Clin Pharmacol. 2018;13(2):120-127. [Content Brief]
[2]. Kim JK, et, al. Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice. Sci Rep. 2021 Mar 17;11(1):6094. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3699 mL | 11.8495 mL | 23.6989 mL | 59.2473 mL |
| 5 mM | 0.4740 mL | 2.3699 mL | 4.7398 mL | 11.8495 mL | |
| 10 mM | 0.2370 mL | 1.1849 mL | 2.3699 mL | 5.9247 mL | |
| 15 mM | 0.1580 mL | 0.7900 mL | 1.5799 mL | 3.9498 mL | |
| 20 mM | 0.1185 mL | 0.5925 mL | 1.1849 mL | 2.9624 mL | |
| 25 mM | 0.0948 mL | 0.4740 mL | 0.9480 mL | 2.3699 mL | |
| 30 mM | 0.0790 mL | 0.3950 mL | 0.7900 mL | 1.9749 mL | |
| 40 mM | 0.0592 mL | 0.2962 mL | 0.5925 mL | 1.4812 mL | |
| 50 mM | 0.0474 mL | 0.2370 mL | 0.4740 mL | 1.1849 mL | |
| 60 mM | 0.0395 mL | 0.1975 mL | 0.3950 mL | 0.9875 mL | |
| 80 mM | 0.0296 mL | 0.1481 mL | 0.2962 mL | 0.7406 mL | |
| 100 mM | 0.0237 mL | 0.1185 mL | 0.2370 mL | 0.5925 mL |
Buspirone hydrochloride 関連分類
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