338962-32-6
Chemical Structure
5M038
- CAS No.: 338962-32-6
- Formula:C17H8F6N4
- Molecular Weight:382.26
IUPAC Name: 9-phenyl-2,4-bis(trifluoromethyl)-[1,2,4]triazolo[4,3-a][1,8]naphthyridine
InChIKey: GHRWOOWATMATRL-UHFFFAOYSA-N
SMILES: FC(F)(F)C1=C2C=CC3=NN=C(N3C2=NC(C(F)(F)F)=C1)C4=CC=CC=C4
Biological Activity: 5M038 is an inhibitor of HIV envelope-mediated fusion with potent inhibitory activity against gp41-mediated membrane fusion. 5M038 prevents the formation of the gp41 post-fusion conformation and inhibits envelope-mediated membrane fusion in cell-cell fusion and viral infectivity assays. 5M038 has shown broad fusion inhibition in tests against multiple HIV-1 subtypes, including M and T strains. 5M038 targets a highly conserved hydrophobic pocket and binds to the gp41 trimer, thereby exerting its inhibitory effect[1].
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5M038 | 5M038 is an inhibitor of HIV envelope-mediated fusion with potent inhibitory activity against gp41-mediated membrane fusion. 5M038 prevents the formation of the gp41 post-fusion conformation and inhibits envelope-mediated membrane fusion in cell-cell fusion and viral infectivity assays. 5M038 has shown broad fusion inhibition in tests against multiple HIV-1 subtypes, including M and T strains. 5M038 targets a highly conserved hydrophobic pocket and binds to the gp41 trimer, thereby exerting its inhibitory effect. | |||||||||||||||||||||
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Keywords
