34408-14-5
34408-14-5
Chemical Structure
8-Chloroadenosine
Synonym(s): 8-Cl-Ado
- CAS No.: 34408-14-5
- Formula:C10H12ClN5O4
- Molecular Weight:301.69
IUPAC Name: (2R,3R,4S,5R)-2-(6-amino-8-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
InChIKey: MHDPPLULTMGBSI-UUOKFMHZSA-N
SMILES: O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2Cl)O[C@@H]1CO
Biological Activity: 8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice[1].
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8-Chloroadenosine | 99.75% | 8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice. | ||||||||||||||||||||
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8-Chloroadenosine (Standard) | ≥98% | 8-Chloroadenosine (Standard) is the analytical standard of 8-Chloroadenosine. This product is intended for research and analytical applications. 8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-1523878-Chloro-arabinoadenosine -
Similarity Score 0.87
HY-1526358-Chloro-2’-O-methyl adenosine -
Similarity Score 0.84
HY-1259278-Aminoadenosine -
Similarity Score 0.83
HY-W0131958-Bromoadenosine -
Similarity Score 0.83
HY-1522968-Methyladenosine -
Similarity Score 0.82
HY-1342918-Chloro-2'-deoxyadenosine -
Similarity Score 0.80
HY-1528358-(Methylamino)adenosine -
Similarity Score 0.80
HY-N6666RVidarabine monohydrate (Standard) -
Similarity Score 0.80
HY-B0228S1Adenosine-13C5 -
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