35334-12-4
Chemical Structure
Azidocillin sodium
- CAS No.: 35334-12-4
- Formula:C16H16N5NaO4S
- Molecular Weight:397.38
InChIKey: DKUPMJBOYNDXNY-YWUHCJSESA-M
SMILES: O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC([C@H](N=[N+]=[N-])C3=CC=CC=C3)=O)N1C2=O)O[Na]
Biological Activity: Azidocillin sodium, a semi-synthetic Penicillin, is an orally active β-lactam antibiotic. Azidocillin sodium bears an azide functionality and retains on-target activity within bacteria. Azidocillin sodium can be used to research osteitis caused by dental surgery, otitis media, enterococcal septicemia and other bacterial infectious diseases[1][2][3]. Azidocillin sodium is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Azidocillin sodium | Azidocillin sodium, a semi-synthetic Penicillin, is an orally active β-lactam antibiotic. Azidocillin sodium bears an azide functionality and retains on-target activity within bacteria. Azidocillin sodium can be used to research osteitis caused by dental surgery, otitis media, enterococcal septicemia and other bacterial infectious diseases. Azidocillin sodium is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | |||||||||||||||||||||
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References
- [1]. Bystedt H, et al. Concentration of azidocillin, erythromycin, doxycycline and clindamycin in dental alveolar serum after single oral doses. Int J Oral Surg. 1977 Apr;6(2):65-74. [Content Brief]
- [2]. Spangler B, et al. Molecular Probes for the Determination of Subcellular Compound Exposure Profiles in Gram-Negative Bacteria. ACS Infect Dis. 2018 Sep 14;4(9):1355-1367. [Content Brief]
- [3]. Bengtsson E, et al. Azidocillin treatment of enterococcal septicemia. Scand J Infect Dis. 1972;4(2):143-8. [Content Brief]
