35815-07-7
Chemical Structure
Herbacitrin
- CAS 番号: 35815-07-7
- Formula:C21H20O12
- Molecular Weight:464.38
InChIKey: RSPZVQZNRINVPE-ZGNDCXKCSA-N
SMILES: OC1=C2C(C(C(O)=C(C3=CC=C(C=C3)O)O2)=O)=C(C=C1O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)O
Biological Activity: Herbacitrin is a HIV-1 reverse transcriptase and integrase inhibitor with IC50 values of 21.5 μM and 2.15 μM, respectively. Herbacitrin inhibits the growth of normal mouse embryonic cells, hybridoma HF cells, and ras/myc-transformed SFME cells, regulates the growth of ras-transformed SFME cells, and exhibits cytotoxic activity against hybridoma HF cells. Herbacitrin can be used in studies related to HIV-1 infection[1][2].
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Herbacitrin | Herbacitrin is a HIV-1 reverse transcriptase and integrase inhibitor with IC50 values of 21.5 μM and 2.15 μM, respectively. Herbacitrin inhibits the growth of normal mouse embryonic cells, hybridoma HF cells, and ras/myc-transformed SFME cells, regulates the growth of ras-transformed SFME cells, and exhibits cytotoxic activity against hybridoma HF cells. Herbacitrin can be used in studies related to HIV-1 infection. | |||||||||||||||||||||
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References
- [1]. Áy É, et al. Flavonol 7-O-Glucoside Herbacitrin Inhibits HIV-1 Replication through Simultaneous Integrase and Reverse Transcriptase Inhibition. Evid Based Complement Alternat Med. 2019;2019:1064793. Published 2019 Feb 3. [Content Brief]
- [2]. Iio M, et al. Effects of Herbacitrin, a Flavonoid, on the Growth of Normal and Transformed Serum-Free Mouse Embryo Cells. Agric Biol Chem. 1990 Oct 1;54(10):2743-2744.
