2. Anti-infection Metabolic Enzyme/Protease
  3. HIV HIV Integrase
  4. Herbacitrin

Herbacitrin is a HIV-1 reverse transcriptase and integrase inhibitor with IC50 values of 21.5 μM and 2.15 μM, respectively. Herbacitrin inhibits the growth of normal mouse embryonic cells, hybridoma HF cells, and ras/myc-transformed SFME cells, regulates the growth of ras-transformed SFME cells, and exhibits cytotoxic activity against hybridoma HF cells. Herbacitrin can be used in studies related to HIV-1 infection.

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Herbacitrin

Herbacitrin Chemical Structure

CAS No. : 35815-07-7

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Herbacitrin Related Antibodies

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Description

Herbacitrin is a HIV-1 reverse transcriptase and integrase inhibitor with IC50 values of 21.5 μM and 2.15 μM, respectively. Herbacitrin inhibits the growth of normal mouse embryonic cells, hybridoma HF cells, and ras/myc-transformed SFME cells, regulates the growth of ras-transformed SFME cells, and exhibits cytotoxic activity against hybridoma HF cells. Herbacitrin can be used in studies related to HIV-1 infection[1][2].

IC50 & Target[1]

HIV-1

 

In Vitro

Herbacitrin (4 days) exhibits dose-dependent cytotoxicity toward MT-4 and MT-2 human T-cell lines, with CC50 values of 27.8 μM and 63.64 μM, respectively[1].
Herbacitrin (2.1 μM; 5 days) significantly inhibits HIV-1 replication in HIV-1-infected MT-4 and MT-2 human T-cell lines, as measured by reduced p24 core protein levels[1].
Herbacitrin (2.15-21.5 μM) significantly inhibits recombinant HIV-1 reverse transcriptase activity at 21.5 μM, but not at 2.15 μM[1].
Herbacitrin (2.15-21.5 μM) significantly inhibits recombinant HIV-1 integrase activity at both 2.15 μM and 21.5 μM, with greater potency at the higher concentration[1].
Herbacitrin (10-50 μM; 6 days) dose-dependently inhibits the growth of normal Balb/c-derived SFME cells, shows biphasic stimulatory/inhibitory effects on ras-transformed Balb/c-derived SFME cells, and exerts only weak growth inhibition on ras/myc-transformed Balb/c-derived SFME cells, with complete inhibition of normal cells occurring at 40-50 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Herbacitrin Related Antibodies

ELISA Assay[1]

Cell Line: HIV-1-infected MT-4, MT-2 human T-cell lines
Concentration: 2.1 μM
Incubation Time: 5 days
Result: Reduced HIV-1 replication in both MT-4 and MT-2 cells, as shown by decreased p24 core protein levels, and exhibited statistically significant differences compared with the negative control.

Cell Proliferation Assay[2]

Cell Line: normal serum-free mouse embryo (SFME) cells, ras-transformed SFME cells, ras/myc-transformed SFME cells (all derived from Balb/c mouse embryonic cells)
Concentration: 10 μM, 20 μM, 30 μM, 40 μM, 50 μM
Incubation Time: 6 days
Result: Markedly inhibited normal SFME cell growth dose-dependently, induced biphasic growth regulation in ras-transformed SFME cells, and weakly suppressed ras/myc-transformed SFME cell proliferation.
Molecular Weight

464.38

Formula

C21H20O12
CAS No.
SMILES

OC1=C2C(C(C(O)=C(C3=CC=C(C=C3)O)O2)=O)=C(C=C1O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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Herbacitrin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Herbacitrin35815-07-7HIVHIV IntegraseHuman immunodeficiency virusras/myc-transformed SFME cellsHIV-1 replicationMT-4 human T-cell linesBalb/c-derived SFME cellshybridoma HF cellsmouse embryo cellsHIV-1 integraseHIV-1 reverse transcriptaseras-transformed SFME cellsMT-2 human T-cell linesInhibitorinhibitorinhibit

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