359715-57-4
Chemical Structure
S23515
- CAS No.: 359715-57-4
- Formula:C10H11BrN2O2
- Molecular Weight:271.11
InChIKey: GUVAJKCAUCHQID-UHFFFAOYSA-N
SMILES: BrC1=C(OCC2OC(N)=NC2)C=CC=C1
Biological Activity: S23515 is a highly selective I1 imidazoline receptor (I1R) agonist with a Ki value of 6.4 nM. S23515 modulates central cardiovascular functions, induces hypotension and bradycardia, shows no affinity for α-adrenergic receptors, and cannot cross the blood-brain barrier. S23515 inhibits oxidosqualene-lanosterol cyclase (OSC) and cholesterol synthesis, induces the production of (24S,25)-Epoxycholesterol (HY-W040150), and upregulates the expression of ABCA1 and ABCG1 in human macrophages. S23515 is applicable to research related to dyslipidemia and hypertension[1][2][3].
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S23515 | S23515 is a highly selective I1 imidazoline receptor (I1R) agonist with a Ki value of 6.4 nM. S23515 modulates central cardiovascular functions, induces hypotension and bradycardia, shows no affinity for α-adrenergic receptors, and cannot cross the blood-brain barrier. S23515 inhibits oxidosqualene-lanosterol cyclase (OSC) and cholesterol synthesis, induces the production of (24S,25)-Epoxycholesterol (HY-W040150), and upregulates the expression of ABCA1 and ABCG1 in human macrophages. S23515 is applicable to research related to dyslipidemia and hypertension. | |||||||||||||||||||||
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References
- [1]. Venteclef N, et al. The imidazoline-like drug S23515 affects lipid metabolism in hepatocyte by inhibiting the oxidosqualene: lanosterol cyclase activity. Biochemical pharmacology. 2005 Apr 01;69(7):1041-8.
- [2]. Bruban V, et al. Respective contributions of alpha-adrenergic and non-adrenergic mechanisms in the hypotensive effect of imidazoline-like drugs. British journal of pharmacology. 2001 May;133(2):261-6.
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[3]. Bousquet P, et al. I(1) imidazoline receptors involved in cardiovascular regulation: where are we and where are we going? Ann N Y Acad Sci. 2003 Dec;1009:228-33.
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