37293-17-7
Chemical Structure
Boanmycin
- CAS No.: 37293-17-7
- Formula:C60H96N20O21S2
- Molecular Weight:1497.66
IUPAC Name: (2R,3S,4S,5R,6R)-2-(((2R,3S,4S,5S,6S)-2-((1R,2S)-2-(6-amino-2-((S)-3-amino-1-(((S)-2,3-diamino-3-oxopropyl)amino)-3-oxopropyl)-5-methylpyrimidine-4-carboxamido)-3-(((2R,3S,4S)-5-(((2S,3R)-1-((2-(4-((3-((4-((3-aminopropyl)amino)butyl)amino)propyl)carbamoyl
InChIKey: FOUFFVYWFNBHHH-YNGSZULRSA-N
SMILES: O=C(C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C)N[C@H](C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@]([C@H](O)C)([H])C(NCCC2=NC(C3=NC(C(NCCCNCCCCNCCCN)=O)=CS3)=CS2)=O)=O)=O)[C@H](C4=CN=CN4)O[C@H]5[C@H]([C@H]([C@@H]([C@@H](O5)CO)O)O)O[C@]6([H])[C@H]([C@H]([C@@H]([C@H](O6)CO)O)OC(N)=O)O
Biological Activity: Boanmycin is an antibiotic with antitumor activity that induces cellular senescence and apoptosis[1][2][3].
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Boanmycin | Boanmycin is an antibiotic with antitumor activity that induces cellular senescence and apoptosis. | |||||||||||||||||||||
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- [1]. Y C Deng, et al. Activity of boanmycin against colorectal cancer. World J Gastroenterol. 2001 Feb;7(1):93-7. [Content Brief]
- [2]. Hao Tang, et al. Effect of boanmycin on apoptosis and cell cycle of human esophageal cancer(Eca-109) cells]. Ai Zheng. 2002 Aug;21(8):855-9. [Content Brief]
- [3]. Peng Chen, et al. The chemotherapeutic drug boanmycin induces cell senescence and senescence-associated secretory phenotype factors, thus acquiring the potential to remodel the tumor microenvironment. Anticancer Drugs. 2016 Feb;27(2):84-8. [Content Brief]
Keywords
