2. Anti-infection Apoptosis
  3. Antibiotic Apoptosis
  4. Boanmycin

Boanmycin is an antibiotic with antitumor activity that induces cellular senescence and apoptosis.

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Boanmycin Chemical Structure

Boanmycin Chemical Structure

CAS No. : 37293-17-7

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Boanmycin Related Antibodies

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Description

Boanmycin is an antibiotic with antitumor activity that induces cellular senescence and apoptosis[1][2][3].

In Vitro

Boanmycin (50-125 μg/mL, 0.5-36 h) can induce apoptosis and block the cell cycle in the G2/M phase in Eca-109 cells[2].
Boanmycin (6.7 µg/mL, 24 h) induces cell senescence[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Boanmycin Related Antibodies

Cell Viability Assay[3]

Cell Line: Human lung fibroblast cell line IMR90, mouse primary osteoblasts (OBs)
Concentration: 6.7 µg/mL
Incubation Time: 24 hours
Result: Showed a 90% positive number of SA-βgal stained cells in IMR90 cells and 95% in OBs compared to 30% in the control group.

RT-PCR[3]

Cell Line: Mouse primary osteoblasts (OBs)
Concentration: 6.7 µg/mL
Incubation Time: 24 hours
Result: Increased senescence-associated secretory phenotype (SASP) factor IL-6 expression up to six-fold.
In Vivo

Boanmycin (BAM) (i.p., 10 or 15 mg/kg, twice a week, 5 weeks) can effectively inhibit the growth of tumors in BALB/c nude mice with HT-29, Hce-8693 or CT-26 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice with HT-29 or Hce-8693 cells[1]
Dosage: 10 or 15 mg/kg
Administration: Intraperitoneal injection; twice a week; 5 weeks
Result: Significantly inhibited tumor growth by 89% at 10 mg/kg and by 92% at 15 mg/kg in mice with HT-29 model, also inhibited tumor growth by 90% at 10 mg/kg and by 92% at 15 mg/kg in mice with Hce-8693 model.
Animal Model: BALB/c nude mice with CT-26 cells[1]
Dosage: 10 mg/kg
Administration: Intramuscular injection; every second day; 10 times
Result: Inhibited subcutaneous tumor growth by 88% and cecal tumor by 99%.
Clinical Trial
Molecular Weight

1497.66

Formula

C60H96N20O21S2
CAS No.
SMILES

O=C(C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C)N[C@H](C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@]([C@H](O)C)([H])C(NCCC2=NC(C3=NC(C(NCCCNCCCCNCCCN)=O)=CS3)=CS2)=O)=O)=O)[C@H](C4=CN=CN4)O[C@H]5[C@H]([C@H]([C@@H]([C@@H](O5)CO)O)O)O[C@]6([H])[C@H]([C@H]([C@@H]([C@H](O6)CO)O)OC(N)=O)O
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Boanmycin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boanmycin37293-17-7AntibioticApoptosisantibioticantitumorapoptosissenescenceInhibitorinhibitorinhibit

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