Boanmycin
Boanmycin is an antibiotic with antitumor activity that induces cellular senescence and apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 37293-17-7
- Formula: C60H96N20O21S2
- Molecular Weight:1497.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Boanmycin (50-125 μg/mL, 0.5-36 h) can induce apoptosis and block the cell cycle in the G2/M phase in Eca-109 cells[2].
Boanmycin (6.7 µg/mL, 24 h) induces cell senescence[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human lung fibroblast cell line IMR90, mouse primary osteoblasts (OBs)
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Concentration:6.7 µg/mL
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Incubation Time:24 hours
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Result:Showed a 90% positive number of SA-βgal stained cells in IMR90 cells and 95% in OBs compared to 30% in the control group.
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Cell Line:Mouse primary osteoblasts (OBs)
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Concentration:6.7 µg/mL
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Incubation Time:24 hours
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Result:Increased senescence-associated secretory phenotype (SASP) factor IL-6 expression up to six-fold.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude mice with HT-29 or Hce-8693 cells[1]
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Dosage:10 or 15 mg/kg
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Administration:Intraperitoneal injection; twice a week; 5 weeks
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Result:Significantly inhibited tumor growth by 89% at 10 mg/kg and by 92% at 15 mg/kg in mice with HT-29 model, also inhibited tumor growth by 90% at 10 mg/kg and by 92% at 15 mg/kg in mice with Hce-8693 model.
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Animal Model:BALB/c nude mice with CT-26 cells[1]
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Dosage:10 mg/kg
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Administration:Intramuscular injection; every second day; 10 times
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Result:Inhibited subcutaneous tumor growth by 88% and cecal tumor by 99%.
Chemical Information
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CAS No. 37293-17-7
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Molecular Weight 1497.66
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Formula C60H96N20O21S2
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SMILES
O=C(C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C)N[C@H](C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@]([C@H](O)C)([H])C(NCCC2=NC(C3=NC(C(NCCCNCCCCNCCCN)=O)=CS3)=CS2)=O)=O)=O)[C@H](C4=CN=CN4)O[C@H]5[C@H]([C@H]([C@@H]([C@@H](O5)CO)O)O)O[C@]6([H])[C@H]([C@H]([C@@H]([C@H](O6)CO)O)OC(N)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Y C Deng, et al. Activity of boanmycin against colorectal cancer. World J Gastroenterol. 2001 Feb;7(1):93-7. [Content Brief]
[2]. Hao Tang, et al. Effect of boanmycin on apoptosis and cell cycle of human esophageal cancer(Eca-109) cells]. Ai Zheng. 2002 Aug;21(8):855-9. [Content Brief]
[3]. Peng Chen, et al. The chemotherapeutic drug boanmycin induces cell senescence and senescence-associated secretory phenotype factors, thus acquiring the potential to remodel the tumor microenvironment. Anticancer Drugs. 2016 Feb;27(2):84-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Boanmycin Related Classifications
HY-147359 Related Classifications
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