374071-46-2
374071-46-2
Chemical Structure
CEP-8983
- CAS No.: 374071-46-2
- Formula:C18H14N2O3
- Molecular Weight:306.32
IUPAC Name: 11-methoxy-4,5,6,7-tetrahydro-1H-cyclopenta[a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione
InChIKey: BWVHYDYUKQEFHG-UHFFFAOYSA-N
SMILES: COC1=CC=CC2=C1C3=C(C(NC4=O)=O)C4=C(CCC5)C5=C3N2
Biological Activity: CEP-8983 is a PARP-1 and PARP-2 inhibitor (IC50: 20 and 6 nM). CEP-8983 is an effective chemosensitizing agent, and can sensitize chemotherapy-resistant cell lines and subcutaneous xenografts to Temozolomide (HY-17364) and Camptothecin (HY-16560)[1].
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CEP-8983 | CEP-8983 is a PARP-1 and PARP-2 inhibitor (IC50: 20 and 6 nM). CEP-8983 is an effective chemosensitizing agent, and can sensitize chemotherapy-resistant cell lines and subcutaneous xenografts to Temozolomide (HY-17364) and Camptothecin (HY-16560). | |||||||||||||||||||||
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References
Keywords
