392659-38-0
Chemical Structure
Ranbezolid
Synonym(s): RBx7644 free base
- CAS No.: 392659-38-0
- Formula:C21H24FN5O6
- Molecular Weight:461.44
IUPAC Name: (S)-N-((3-(3-fluoro-4-(4-((5-nitrofuran-2-yl)methyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
InChIKey: PWHNTOQANLCTHN-KRWDZBQOSA-N
SMILES: CC(NC[C@H]1CN(C2=CC=C(N3CCN(CC4=CC=C([N+]([O-])=O)O4)CC3)C(F)=C2)C(O1)=O)=O
Biological Activity: Ranbezolid (RBx7644 free base) is an orally active, oxazolidinone antibiotic against Gram-positive and Gram-negative anaerobes including Staphylococcus aureus, Staphylococcus epidermidis and Bacteroides fragilis. Ranbezolid can inhibit the 50s ribosomal subunit with an IC50 of 17 μM for bacterial ribosomes. Ranbezolid interferes cell wall and lipid synthesis. Ranbezolid can rapidly kill bacteria, significantly reduce bacterial load, and has better cardiovascular safety. Ranbezolid can be used for the study of antibiotics for anaerobic bacteria[1][2][3].
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Ranbezolid | Ranbezolid (RBx7644 free base) is an orally active, oxazolidinone antibiotic against Gram-positive and Gram-negative anaerobes including Staphylococcus aureus, Staphylococcus epidermidis and Bacteroides fragilis. Ranbezolid can inhibit the 50s ribosomal subunit with an IC50 of 17 μM for bacterial ribosomes. Ranbezolid interferes cell wall and lipid synthesis. Ranbezolid can rapidly kill bacteria, significantly reduce bacterial load, and has better cardiovascular safety. Ranbezolid can be used for the study of antibiotics for anaerobic bacteria. | |||||||||||||||||||||
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- [1]. Kalia V, et al. Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. Antimicrob Agents Chemother. 2009 Apr;53(4):1427-33. [Content Brief]
- [2]. Mathur T, et al. Anti-anaerobic potential of ranbezolid: insight into its mechanism of action against Bacteroides fragilis. Int J Antimicrob Agents. 2013 Jan;41(1):36-40. [Content Brief]
- [3]. Naruganahalli KS, et al. Ranbezolid, a novel oxazolidinone antibacterial: in vivo characterisation of monoamine oxidase inhibitory potential in conscious rats. Eur J Pharmacol. 2006 Sep 18;545(2-3):167-72. [Content Brief]
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