418800-15-4
418800-15-4
Chemical Structure
Lenaldekar
Synonym(s): LDK
- CAS No.: 418800-15-4
- Formula:C18H14N4
- Molecular Weight:286.33
IUPAC Name: (E)-8-(2-((1H-indol-3-yl)methylene)hydrazinyl)quinoline
InChIKey: QLMFOQYHZJSYJF-CIAFOILYSA-N
SMILES: C1(/C=N/NC2=C3N=CC=CC3=CC=C2)=CNC4=C1C=CC=C4
Biological Activity: Lenaldekar (LDK) inhibits human and murine T-cell expansiomn. Lenaldekar inhibits autoimmune T cell response. Lenaldekar also induces cancer cell apoptosis. Lenaldekar can be used for T-cell mediated autoimmune diseases research[1][2].
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Lenaldekar | Lenaldekar (LDK) inhibits human and murine T-cell expansiomn. Lenaldekar inhibits autoimmune T cell response. Lenaldekar also induces cancer cell apoptosis. Lenaldekar can be used for T-cell mediated autoimmune diseases research. | |||||||||||||||||||||
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References
- [1]. Cusick MF, et al. Human T cell expansion and experimental autoimmune encephalomyelitis inhibited by Lenaldekar, a small molecule discovered in a zebrafish screen. J Neuroimmunol. 2012 Mar;244(1-2):35-44. [Content Brief]
- [2]. Ridges S, et al, et al. Zebrafish screen identifies novel compound with selective toxicity against leukemia. Blood. 2012 Jun 14;119(24):5621-31. [Content Brief]
