Lenaldekar
Lenaldekar (LDK) inhibits human and murine T-cell expansiomn. Lenaldekar inhibits autoimmune T cell response. Lenaldekar also induces cancer cell apoptosis. Lenaldekar can be used for T-cell mediated autoimmune diseases research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 418800-15-4
- Formel: C18H14N4
- Molecular Weight:286.33
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Lenaldekar (4 days) inhibits CD3+ T cell proliferation in a dose-dependent manner with an IC50 of 3 μM[1].
Lenaldekar (3 μM, 4 days) reduces a memory T cell response to influenza antigen H3[1].
Lenaldekar (48 h) shows cytotoxicity in Jurkat T-ALL cell, with IC50s of 0.8 μM, and induces apoptosis (1 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Lenaldekar (16 mg/kg, i.p., twice daily) inhibits tumor progession in a mouse xenograft model of T-cell acute lymphoblastic leukemia (T-ALL)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 418800-15-4
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Molecular Weight 286.33
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Formel C18H14N4
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SMILES
C1(/C=N/NC2=C3N=CC=CC3=CC=C2)=CNC4=C1C=CC=C4
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Synonyms
LDK
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Cusick MF, et al. Human T cell expansion and experimental autoimmune encephalomyelitis inhibited by Lenaldekar, a small molecule discovered in a zebrafish screen. J Neuroimmunol. 2012 Mar;244(1-2):35-44. [Content Brief]
[2]. Ridges S, et al, et al. Zebrafish screen identifies novel compound with selective toxicity against leukemia. Blood. 2012 Jun 14;119(24):5621-31. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Lenaldekar Related Classifications
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