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  3. Lenaldekar

Lenaldekar (LDK) inhibits human and murine T-cell expansiomn. Lenaldekar inhibits autoimmune T cell response. Lenaldekar also induces cancer cell apoptosis. Lenaldekar can be used for T-cell mediated autoimmune diseases research.

For research use only. We do not sell to patients.

Lenaldekar Chemical Structure

Lenaldekar Chemical Structure

CAS No. : 418800-15-4

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Description

Lenaldekar (LDK) inhibits human and murine T-cell expansiomn. Lenaldekar inhibits autoimmune T cell response. Lenaldekar also induces cancer cell apoptosis. Lenaldekar can be used for T-cell mediated autoimmune diseases research[1][2].

In Vitro

Lenaldekar (4 days) inhibits CD3+ T cell proliferation in a dose-dependent manner with an IC50 of 3 μM[1].
Lenaldekar (3 μM, 4 days) reduces a memory T cell response to influenza antigen H3[1].
Lenaldekar (48 h) shows cytotoxicity in Jurkat T-ALL cell, with IC50s of 0.8 μM, and induces apoptosis (1 μM)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Lenaldekar (40 mg/kg per day, i.p.) inhibits experimental autoimmune encephalomyelitis (EAE) relapse in mice sensitized with the encephalitogenic PLP139-151 peptide[1].
Lenaldekar (16 mg/kg, i.p., twice daily) inhibits tumor progession in a mouse xenograft model of T-cell acute lymphoblastic leukemia (T-ALL)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

286.33

Formula

C18H14N4

CAS No.
SMILES

C1(/C=N/NC2=C3N=CC=CC3=CC=C2)=CNC4=C1C=CC=C4

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Lenaldekar
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HY-121662
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