4214-23-7
4214-23-7
Chemical Structure
2′-OMe-UMP
- CAS No.: 4214-23-7
- Formula:C10H15N2O9P
- Molecular Weight:338.21
InChIKey: FHMMECZNEPGJSJ-ZOQUXTDFSA-N
SMILES: O[C@H]1[C@@H](OC)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(O)(O)=O
Biological Activity: 2′-OMe-UMP is a primer extension terminator. When 2′-OMe-UMP is present at the -1 position of the primer chain, its 2′-OMe group sterically clashes with the base of the next NTP at the active site (+1 position). This clash weakens the base-stacking interaction between the +1 position and the -1 position, thereby reducing the binding affinity of the next substrate[1].
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2′-OMe-UMP | 2′-OMe-UMP is a primer extension terminator. When 2′-OMe-UMP is present at the -1 position of the primer chain, its 2′-OMe group sterically clashes with the base of the next NTP at the active site (+1 position). This clash weakens the base-stacking interaction between the +1 position and the -1 position, thereby reducing the binding affinity of the next substrate. | |||||||||||||||||||||
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