436133-68-5
436133-68-5
Chemical Structure
Kobe0065
- CAS No.: 436133-68-5
- Formula:C15H11ClF3N5O4S
- Molecular Weight:449.79
IUPAC Name: N-(3-chloro-4-methylphenyl)-2-(2,6-dinitro-4-(trifluoromethyl)phenyl)hydrazine-1-carbothioamide
InChIKey: KSJVAYBCXSURMQ-UHFFFAOYSA-N
SMILES: FC(C1=CC([N+]([O-])=O)=C(NNC(NC2=CC=C(C)C(Cl)=C2)=S)C([N+]([O-])=O)=C1)(F)F
Biological Activity: Kobe0065 is a novel and effective inhibitor of Ras-Raf interaction, competitively inhibiting the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46±13 μM.
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Kobe0065 | 99.93% | Kobe0065 is a novel and effective inhibitor of Ras-Raf interaction, competitively inhibiting the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46±13 μM. | ||||||||||||||||||||
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Keywords
