440120-55-8
Chemical Structure
RS-2982
- CAS No.: 440120-55-8
- Formula:C26H25N3O2
- Molecular Weight:411.50
InChIKey: WJDSQQKGJIPSRE-UHFFFAOYSA-N
SMILES: O=C1NC2=CC(C(N3CCC(CC3)CC4=CC=CC=C4)=O)=CC=C2NC5=C1C=CC=C5
Biological Activity: RS-2982 is a retinoic acid receptor-related orphan receptor A (RORA) agonist. RS-2982 enhances the promoter activity of MIR122 via the RORA binding site, and promotes the expression and secretion of MIR122. RS-2982 reduces the expression of hepatic triglyceride biosynthetic enzymes, hepatic lipotoxicity, hepatic fibrosis and body weight in diet-fed mice, while improving insulin resistance. RS-2982 can be used in the research of non-alcoholic steatohepatitis[1].
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RS-2982 | RS-2982 is a retinoic acid receptor-related orphan receptor A (RORA) agonist. RS-2982 enhances the promoter activity of MIR122 via the RORA binding site, and promotes the expression and secretion of MIR122. RS-2982 reduces the expression of hepatic triglyceride biosynthetic enzymes, hepatic lipotoxicity, hepatic fibrosis and body weight in diet-fed mice, while improving insulin resistance. RS-2982 can be used in the research of non-alcoholic steatohepatitis. | |||||||||||||||||||||
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