457657-33-9
457657-33-9
Chemical Structure
PA451
- CAS No.: 457657-33-9
- Formula:C25H35N3O3
- Molecular Weight:425.56
InChIKey: PMHLEYZHMPYVLJ-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C(N(C)C2=C(OCCCCC)C=C(C(C)(CCC3(C)C)C)C3=C2)N=C1)O
Biological Activity: PA451 is an RXR antagonist that selectively antagonizes the RXR site in the RXR-RAR heterodimer. PA451 can be used for research on Pseudomonas aeruginosa pneumonia[1][2][3].
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PA451 | PA451 is an RXR antagonist that selectively antagonizes the RXR site in the RXR-RAR heterodimer. PA451 can be used for research on Pseudomonas aeruginosa pneumonia. | |||||||||||||||||||||
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References
- [1]. Takahashi B, et al. Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions. Journal of medicinal chemistry. 2002 Aug 01;45(16):3327-30.
- [2]. Zhu Z, et al. Single-dose dual-indication nanoparticle vaccine co-displaying Pseudomonas aeruginosa antigen and tetanus toxin fragment confers durable protection against mixed exposure. Mater Today Bio. 2026 Jun 13;39:103354.
- [3]. Pérez Santín E, et al. Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers. Journal of medicinal chemistry. 2009 May 28;52(10):3150-8.
