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Cat. No.: HY-189028

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PA451

PA451 is an RXR antagonist that selectively antagonizes the RXR site in the RXR-RAR heterodimer. PA451 can be used for research on Pseudomonas aeruginosa pneumonia.

For research use only. We do not sell to patients.

CAS No.: 457657-33-9
Formula: C₂₅H₃₅N₃O₃
Molecular Weight:425.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (287 KB)

PA451 Chemical Structure

CAS No.: 457657-33-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PA451 is an RXR antagonist that selectively antagonizes the RXR site in the RXR-RAR heterodimer. PA451 can be used for research on Pseudomonas aeruginosa pneumonia^[1]^[2]^[3].

IC₅₀ & Target

^[1]^[2]^[3]

RXR α

RXR β

RXR γ

All RAR/RXR Isoforms :

In Vitro

Anti-cancerOthers

Anti-cancer

PA451 (compound 6a) selectively inhibits RXR agonist-driven retinoid synergy in HL-60 cells, reducing Am80 (Tamibarotene) (HY-14652) plus PA024-induced differentiation at 1 μM without affecting Am80 alone^[1].

Others

PA451 dose-dependently antagonizes PA024-induced RXRα/β/γ transactivation, with the strongest potency against RXRα^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 457657-33-9
Molecular Weight 425.56
Formula C₂₅H₃₅N₃O₃
SMILES

O=C(C1=CN=C(N(C)C2=C(OCCCCC)C=C(C(C)(CCC3(C)C)C)C3=C2)N=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (287 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Takahashi B, et al. Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions. Journal of medicinal chemistry. 2002 Aug 01;45(16):3327-30.

[2]. Zhu Z, et al. Single-dose dual-indication nanoparticle vaccine co-displaying Pseudomonas aeruginosa antigen and tetanus toxin fragment confers durable protection against mixed exposure. Mater Today Bio. 2026 Jun 13;39:103354.

[3]. Pérez Santín E, et al. Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers. Journal of medicinal chemistry. 2009 May 28;52(10):3150-8.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PA451

All RAR/RXR Isoforms