4589-95-1
Chemical Structure
Deacetyltanghinin
- CAS No.: 4589-95-1
- Formula:C30H44O9
- Molecular Weight:548.66
InChIKey: LVGNJQMAMYJAIL-FWMNQDIBSA-N
SMILES: O[C@@]12[C@@]34[C@@](C[C@@]5([H])[C@@]([C@@]4([H])CC[C@@]1([C@@H](C(CO6)=CC6=O)CC2)C)(CC[C@@H](C5)O[C@H]7[C@H]([C@@H]([C@H]([C@@H](O7)C)O)OC)O)C)([H])O3
Biological Activity: Deacetyltanghinin is a selective inhibitor targeting Na+/K+ ATPase, acting through non-covalent binding but is highly cardiotoxic. Deacetyltanghinin inhibits Na+/K+ ATPase activity, induces cancer cell apoptosis (involving caspase pathway activation), and at the same time affect the TXA2-PGI2 balance in the rabbit heart. Deacetyltanghinin has significant anti-cancer activity and is mainly used in the research field of targeted therapy of malignant tumors such as breast cancer and lung cancer. At the same time, attention should be paid to the regulation of its cardiotoxicity[1][2].
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Deacetyltanghinin | Deacetyltanghinin is a selective inhibitor targeting Na+/K+ ATPase, acting through non-covalent binding but is highly cardiotoxic. Deacetyltanghinin inhibits Na+/K+ ATPase activity, induces cancer cell apoptosis (involving caspase pathway activation), and at the same time affect the TXA2-PGI2 balance in the rabbit heart. Deacetyltanghinin has significant anti-cancer activity and is mainly used in the research field of targeted therapy of malignant tumors such as breast cancer and lung cancer. At the same time, attention should be paid to the regulation of its cardiotoxicity. | |||||||||||||||||||||
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- [1]. Chan, et al. Cerbera are coastal trees with promising anticancer properties but lethal toxicity: A short review. Journal of Chinese Pharmaceutical Sciences 25.3 (2016): 161.
- [2]. Lasserre B, et al. Effects of deacetyltanghinin, a cardiotonic glycoside from Cerbera odollam Gaerth leaves, on the TXA2-PGI2 balance in isolated rabbit heart. Medical science research 20.18 (1992): 667-669.
Keywords
