477546-27-3
477546-27-3
Chemical Structure
NLRP3-IN-78
- CAS No.: 477546-27-3
- Formula:C12H5Cl2N3O4S2
- Molecular Weight:390.22
SMILES: ClC1=CC(C2=CSC(NC(C3=CC=C([N+]([O-])=O)O3)=O)=N2)=C(Cl)S1
Biological Activity: NLRP3-IN-78 (compound 21) is a NLRP3 inhibitor with the inhibition rate of 46.72% in GSDMD-induced pyroptosis at 5 μM. NLRP3-IN-78 binds to the NLRP3 protein and inhibits GSDMD-NT oligomerization. NLRP3-IN-78 also inhibits GSDMD cleavage, and upstream NF-κB signaling, demonstrating its anti-inflammatory activity[1].
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NLRP3-IN-78 | NLRP3-IN-78 (compound 21) is a NLRP3 inhibitor with the inhibition rate of 46.72% in GSDMD-induced pyroptosis at 5 μM. NLRP3-IN-78 binds to the NLRP3 protein and inhibits GSDMD-NT oligomerization. NLRP3-IN-78 also inhibits GSDMD cleavage, and upstream NF-κB signaling, demonstrating its anti-inflammatory activity. | |||||||||||||||||||||
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References
Keywords
