NLRP3-IN-78
NLRP3-IN-78 (compound 21) is a NLRP3 inhibitor with the inhibition rate of 46.72% in GSDMD-induced pyroptosis at 5 μM. NLRP3-IN-78 binds to the NLRP3 protein and inhibits GSDMD-NT oligomerization. NLRP3-IN-78 also inhibits GSDMD cleavage, and upstream NF-κB signaling, demonstrating its anti-inflammatory activity.
For research use only. We do not sell to patients.
- CAS No.: 477546-27-3
- Formula: C12H5Cl2N3O4S2
- Molecular Weight:390.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 477546-27-3
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Molecular Weight 390.22
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Formula C12H5Cl2N3O4S2
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SMILES
ClC1=CC(C2=CSC(NC(C3=CC=C([N+]([O-])=O)O3)=O)=N2)=C(Cl)S1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NLRP3-IN-78 Related Classifications
HY-172788 Related Classifications
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