481-85-6
481-85-6
Chemical Structure
Menadiol
Synonym(s): Dihydrovitamin K3
- No. CAS: 481-85-6
- Formula:C11H10O2
- Molecular Weight:174.20
IUPAC Name: 2-methylnaphthalene-1,4-diol
InChIKey: ZJTLZYDQJHKRMQ-UHFFFAOYSA-N
SMILES: CC1=C(C2=CC=CC=C2C(=C1)O)O
Biological Activity: Menadiol (Dihydrovitamin K3) is a menadione analog that acts as an electron donor. Menadiol transfers electrons to the heme bL of E. coli nitrate reductase A and, via heme bH, to the catalytic NarGH dimer. Menadiol drives ATP-dependent NAD⁺ reduction (reverse electron transport) in submitochondrial particles. Menadiol selectively inhibits the growth of lymphoid tumor cells. Menadiol enhances the growth-inhibitory effects of Mechlorethamine, Vincristine (HY-N0488A), and Dexamethasone (HY-14648) on tumor cells, converting a drug-resistant phenotype to a sensitive phenotype. Menadiol is used in research related to lymphoid tumors[1][2][3].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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Menadiol | 97.0% | Menadiol (Dihydrovitamin K3) is a menadione analog that acts as an electron donor. Menadiol transfers electrons to the heme bL of E. coli nitrate reductase A and, via heme bH, to the catalytic NarGH dimer. Menadiol drives ATP-dependent NAD⁺ reduction (reverse electron transport) in submitochondrial particles. Menadiol selectively inhibits the growth of lymphoid tumor cells. Menadiol enhances the growth-inhibitory effects of Mechlorethamine, Vincristine (HY-N0488A), and Dexamethasone (HY-14648) on tumor cells, converting a drug-resistant phenotype to a sensitive phenotype. Menadiol is used in research related to lymphoid tumors. | ||||||||||||||||||||
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Menadiol (Standard) | ≥98% | Menadiol (Standard) (Dihydrovitamin K3 (Standard)) is the analytical standard of Menadiol (HY-W128525). This product is intended for research and analytical applications. Menadiol (Dihydrovitamin K3) is a menadione analog that acts as an electron donor. Menadiol transfers electrons to the heme bL of E. coli nitrate reductase A and, via heme bH, to the catalytic NarGH dimer. Menadiol drives ATP-dependent NAD⁺ reduction (reverse electron transport) in submitochondrial particles. Menadiol selectively inhibits the growth of lymphoid tumor cells. Menadiol enhances the growth-inhibitory effects of Mechlorethamine, Vincristine (HY-N0488A), and Dexamethasone (HY-14648) on tumor cells, converting a drug-resistant phenotype to a sensitive phenotype. Menadiol is used in research related to lymphoid tumors. | ||||||||||||||||||||
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1,2-Dihydroxynaphthalene | 98.88% | 1,2-Dihydroxynaphthalene (1,2-Naphthalenediol) is a metabolic intermediate of Naphthalene and a precursor for the formation of 1,2-Naphthoquinone, and is also the most sensitive biomarker of Naphthalene exposure in humans. 1,2-Dihydroxynaphthalene inhibits the AMPK/SIRT3 pathway and activates acetylated p53 and NF-κB by inducing oxidative stress, leading to G2/M cell cycle arrest, senescence, and apoptosis, while also damaging DNA through the formation of depurination adducts, thereby causing mutations. 1,2-Dihydroxynaphthalene can be used in research on cancer and cataracts. | ||||||||||||||||||||
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NSC111552 | NSC111552 is a potent SARS-CoV-2 NSP14 MTase inhibitor. NSC111552 inhibits the FL-NAH binding to the SARS-CoV-2 NSP14 MTase with an IC50 of 5.1 μM. | |||||||||||||||||||||
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2-Methyl-1-naphthol | 2-Methyl-1-naphthol is a key precursor in the synthesis of Vitamin K3. 2-Methyl-1-naphthol is can be used for the research of Vitamin K Deficiency. | |||||||||||||||||||||
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Vitamin K5 | Vitamin K5 (Synkamin) is a photosensitizer and a antimicrobial agent. Vitamin K5 is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 induces apoptosis of colon 26 cells. Vitamin K5 can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages. | |||||||||||||||||||||
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Naphthoresorcinol | 99.49% | Naphthoresorcinol (1,3-Dihydroxynaphthalene) is a fluorescent dye (λex=330 nm, λem=380 nm) that can react with the NPPD (a tracer) and concentrated HCl and develop a red color. Naphthoresorcinol could be used as a background electrolyte (BGE) to determine the carbohydrates. | ||||||||||||||||||||
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Vitamin K5 hydrochloride (Standard) | ≥98% | Vitamin K5 (hydrochloride) (Standard) is the analytical standard of Vitamin K5 (hydrochloride). This product is intended for research and analytical applications. Vitamin K5 hydrochloride is a photosensitizer and a antimicrobial agent. Vitamin K5 hydrochloride is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 hydrochloride induces apoptosis of colon 26 cells. Vitamin K5 hydrochloride can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages. | ||||||||||||||||||||
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2,3-Dihydroxynaphthalene | 98.62% | Naphthalene-2,3-diol is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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1,4-Dihydroxy-2-naphthoic acid (Standard) | ≥98% | 1,4-Dihydroxy-2-naphthoic acid (Standard) is the analytical standard for 1,4-Dihydroxy-2-naphthoic acid (HY-W014701). 1,4-Dihydroxy-2-naphthoic acid is an orally active aryl hydrocarbon receptor (AhR) agonist and a bifidogenic growth stimulator. 1,4-Dihydroxy-2-naphthoic acid can improve the motor dysfunction in parkinson's disease (PD) model through AhR-dependent and -independent pathways. 1,4-Dihydroxy-2-naphthoic acid exerts anti-inflammatory effects by regulating the gut microbiota (such as promoting the proliferation of Bifidobacterium) and directly regulating the host immune system. 1,4-Dihydroxy-2-naphthoic acid induces apoptosis through G0/G1 cell cycle arrest in human keratinocyte to inhibit psoriasis. | ||||||||||||||||||||
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Naphthohydroquinone | Naphthohydroquinone is a compound featuring a naphthalene ring structure with two hydroxyl groups. Naphthohydroquinone exhibits significant cytotoxicity and antitumor activity in some of its derivatives. | |||||||||||||||||||||
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1,5-Dihydroxynaphthalene (Standard) | ≥98% | 1,5-Dihydroxynaphthalene (Standard) is the analytical standard of 1,5-Dihydroxynaphthalene. This product is intended for research and analytical applications. | ||||||||||||||||||||
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References
- [1]. Zhao Z, et al. Effects of site-directed mutations on heme reduction in Escherichia coli nitrate reductase A by menaquinol: a stopped-flow study. Biochemistry. 2003 Dec 09;42(48):14225-33. [Content Brief]
- [2]. Taggart WV, et al. Menadiol as an electron donor for reversed oxidative phosphorylation in submitochondrial particles. Biochim Biophys Acta. 1972 Jun 23;267(3):439-43. [Content Brief]
- [3]. Su YZ, et al. Selective enhancement by menadiol of in vitro drug activity in human lymphatic neoplasms. Cancer treatment reports. 1987 Jun;71(6):619-25.
