513-10-0
Chemical Structure
Echothiopate iodide
Synonym(s): Echothiophate iodide
- CAS No.: 513-10-0
- Formula:C9H23INO3PS
- Molecular Weight:383.23
IUPAC Name: 2-((diethoxyphosphoryl)thio)-N,N,N-trimethylethan-1-aminium iodide
InChIKey: OVXQHPWHMXOFRD-UHFFFAOYSA-M
SMILES: O=P(SCC[N+](C)(C)C)(OCC)OCC.[I-]
Biological Activity: Echothiopate iodide (Echothiophate iodide) is an acetylcholinesterase (AChE) inhibitor. Echothiopate iodide irreversibly inhibits acetylcholinesterase, prevents the enzymatic hydrolysis of acetylcholine, and increases the local acetylcholine concentration in the ciliary muscle, thereby driving muscarinic receptor downregulation and regulatory hyposensitivity to Pilocarpine Hydrochloride. Echothiopate iodide can be used in the study of glaucoma[1][2].
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Echothiopate iodide | Echothiopate iodide (Echothiophate iodide) is an acetylcholinesterase (AChE) inhibitor. Echothiopate iodide irreversibly inhibits acetylcholinesterase, prevents the enzymatic hydrolysis of acetylcholine, and increases the local acetylcholine concentration in the ciliary muscle, thereby driving muscarinic receptor downregulation and regulatory hyposensitivity to Pilocarpine Hydrochloride. Echothiopate iodide can be used in the study of glaucoma. | |||||||||||||||||||||
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References
- [1]. Gabelt BT, et al. H-7 effect on outflow facility after trabecular obstruction following long-term echothiophate treatment in monkeys. Investigative ophthalmology & visual science. 2004 Aug;45(8):2732-6.
- [2]. George C, et al. Regulation of acetylcholine synthesis in normal and neurotropic viral infected sympathetic ganglia. Brain Res. 1982 Jun 24;242(2):255-60.
