519-37-9
Chemical Structure
Etofylline
Synonym(s): 7-(β-Hydroxyethyl)theophylline
- CAS No.: 519-37-9
- Formula:C9H12N4O3
- Molecular Weight:224.22
IUPAC Name: 7-(2-hydroxyethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
InChIKey: NWPRCRWQMGIBOT-UHFFFAOYSA-N
SMILES: O=C(N1C)N(C)C2=C(N(CCO)C=N2)C1=O
Biological Activity: Etofylline (7-(β-Hydroxyethyl) theophylline) is an oral bronchodilator with anti-inflammatory effects. Etofylline inhibits phosphodiesterase and prevents the degradation of cAMP (cyclic adenosine monophosphate), leading to smooth muscle relaxation, reducing inflammatory responses and improving respiratory function. Etofylline affects the development of zebrafish embryos[1][2][3].
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Etofylline | 99.72% | Etofylline (7-(β-Hydroxyethyl) theophylline) is an oral bronchodilator with anti-inflammatory effects. Etofylline inhibits phosphodiesterase and prevents the degradation of cAMP (cyclic adenosine monophosphate), leading to smooth muscle relaxation, reducing inflammatory responses and improving respiratory function. Etofylline affects the development of zebrafish embryos. | ||||||||||||||||||||
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Etofylline (Standard) | ≥98% | Etofylline (Standard) is the analytical standard of Etofylline. This product is intended for research and analytical applications. Etofylline (7-(β-Hydroxyethyl)theophylline) is a N-7-substituted derivative of Theophylline. Etofylline is a bronchodilator which can be used for the research of asthma. Etofylline is also an anticholesteremic and reduces total cholesterol level in the blood. | ||||||||||||||||||||
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Etofylline-d6 | 7-(β-Hydroxyethyl)theophylline-d6 (Etophyllie-d6, Hydoxyethyltheophyllie-d6) is deuterium labeled 7-(β-Hydroxyethyl)theophylline. | |||||||||||||||||||||
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- [1]. Wattanaporn Tavipatana, et al.Etophylline and theophylline pharmacokinetics when administered concomitantly in rabbits. International Journal of Pharmaceutics. Volume 30, Issues 2–3
- [2]. Chandrakantsing V Pardeshi ,et al. Mannose-anchored N,N,N-trimethyl chitosan nanoparticles for pulmonary administration of etofylline. Int J Biol Macromol. 2020 Dec 15;165(Pt A):445-459. [Content Brief]
- [3]. Ram Manohar Basnet, et al. Zebrafish Embryo as an In Vivo Model for Behavioral and Pharmacological Characterization of Methylxanthine Drugs. Int J Mol Sci. 2017 Mar 9;18(3):596. [Content Brief]
