524055-93-4
524055-93-4
Chemical Structure
CD38-IN-4
- CAS No.: 524055-93-4
- Formula:C18H23N5
- Molecular Weight:309.42
IUPAC Name: 7-ethyl-4-methyl-N-(4,6,6-trimethyl-1,6-dihydropyrimidin-2-yl)quinazolin-2-amine
InChIKey: MNTVDRZFXXQEPQ-UHFFFAOYSA-N
SMILES: N=1C(=NC(=C2C=CC(=CC12)CC)C)NC3=NC(=CC(N3)(C)C)C
Biological Activity: CD38-IN-4 is a CD38 inhibitor. CD38-IN-4 inhibits CD38 hydrolase enzymatic activity through mixed inhibition kinetics, binding partially inside and partially outside the NAD+ catalytic pocket. CD38-IN-4 acts as a DNA-binding agent. CD38-IN-4 can be used for research on neuroblastoma[1][2].
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CD38-IN-4 | CD38-IN-4 is a CD38 inhibitor. CD38-IN-4 inhibits CD38 hydrolase enzymatic activity through mixed inhibition kinetics, binding partially inside and partially outside the NAD+ catalytic pocket. CD38-IN-4 acts as a DNA-binding agent. CD38-IN-4 can be used for research on neuroblastoma. | |||||||||||||||||||||
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References
- [1]. Mills CM, et al. Stimulation of natural killer cells with small molecule inhibitors of CD38 for the treatment of neuroblastoma. Chemical science. 2023 Feb 22;14(8):2168-2182.
- [2]. Glass LS, et al. Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound library. Bioorganic & medicinal chemistry letters. 2010 Mar 01;20(5):1685-8.
