526-07-8
526-07-8
Chemical Structure
Sesamolin
- CAS No.: 526-07-8
- Formula:C20H18O7
- Molecular Weight:370.35
IUPAC Name: 5-(((1R,3aR,4S,6aR)-4-(benzo[d][1,3]dioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl)oxy)benzo[d][1,3]dioxole
InChIKey: ZZMNWJVJUKMZJY-AFHBHXEDSA-N
SMILES: [H][C@@]12[C@@](CO[C@@H]2C3=CC(OCO4)=C4C=C3)([H])[C@H](OC1)OC5=CC(OCO6)=C6C=C5
Biological Activity: Sesamolin, isolated from Sesamum indicum, has antioxidative activity, Sesamolin inhibits lipid peroxidation and shows neuroprotection effect. Sesamolinl potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and caspase-3 but not ERK-MAPK expression. Sesamolin is orally active[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sesamolin | 98.51% | Sesamolin, isolated from Sesamum indicum, has antioxidative activity, Sesamolin inhibits lipid peroxidation and shows neuroprotection effect. Sesamolinl potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and caspase-3 but not ERK-MAPK expression. Sesamolin is orally active. | ||||||||||||||||||||
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Sesamolin (Standard) | ≥98% | Sesamolin (Standard) is the analytical standard of Sesamolin. This product is intended for research and analytical applications. Sesamolin, isolated from Sesamum indicum, has antioxidative activity, Sesaminol inhibits lipid peroxidation and shows neuroprotection effect. Sesamolin potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and caspase-3 but not ERK-MAPK expression. | ||||||||||||||||||||
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(-)-Sesamin | 99.17% | (-)-Sesamin isolated from Asarum forbesii Maxim, is an isomer of Sesamin. Sesamin is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. | ||||||||||||||||||||
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Sesamin (Standard) | 98.72% | Sesamin (Standard) is the analytical standard of Sesamin. This product is intended for research and analytical applications. Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia. | ||||||||||||||||||||
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(-)-Asarinin | 99.97% | (-)-Asarinin is a tetrahydrofurofurano lignan with various biological activities. (-)-Asarinin induces apoptosis in cancer cells. (-)-Asarinin promotes mitochondrial ROS accumulation, inhibits the STAT3 signaling pathway and induces apoptosis in precancerous cells. (-)-Asarinin is a Src family kinase inhibitor that suppresses mast cell activation. (-)-Asarinin is a non-competitive Δ5-desaturase inhibitor with a Ki of 0.28 mM. (-)-Asarinin possesses pain relief, anti-viral, anti-allergic and anti-tuberculous bacilli, and anti-tumor effects. | ||||||||||||||||||||
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Asarinin | 99.84% | Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb. | ||||||||||||||||||||
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DL-Asarinin | DL-Asarinin (compound 88) is a natural product that can be found in waste leaves of Cinnamomum camphora. | |||||||||||||||||||||
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Phrymarolin V | Phrymarolin V is a natural lignan. | |||||||||||||||||||||
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Sesaminol | Sesaminol is an orally active antioxidant. Sesaminol induces G1 phase arrest and inhibits cancer cell growth by binding to ANT2, inhibiting mTORC1, and promoting cyclin D1 degradation; it also activates Nrf2/NQO1, inhibits ROS- and neurotoxin-induced apoptosis (apoptosis), reduces α-synuclein (α-synuclein) and Aβ oligomerization/fibril formation, and promotes M2 microglial polarization. Sesaminol can be used in research on cancer, Parkinson's disease, obesity, Alzheimer's disease, colitis, cognitive decline, and liver diseases. | |||||||||||||||||||||
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Paulownin | 99.88% | Paulownin, a component of wood of Paulownia tomentosa Steud, is a constituent of medicinal plants. | ||||||||||||||||||||
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Piperitol | Piperitol is a compound isolated from the Tibetan medicinal plant Lancea tibetica. | |||||||||||||||||||||
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Dihydrosesamin | Dihydrosesamin is a Lignans product that can be isolated from the young shoots of Chamaecyparis obtusa cv. Breviramea.. | |||||||||||||||||||||
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References
- [1]. Dorothea Bedigian, et al. Sesamin, sesamolin and the origin of sesame. Biochemical Systematics and Ecology. Volume 13, Issue 2, 23 May 1985, Pages 133-139.
- [2]. Myung-Hwa Kang, et al. Sesamolin Inhibits Lipid Peroxidation in Rat Liver and Kidney. The Journal of Nutrition, Volume 128, Issue 6, June 1998, Pages 1018–1022.
- [3]. Rolis Chien‐Wei Hou, et al. Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells. [Content Brief]
- [4]. Lim JS, et al. Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats. Br J Nutr. 2007 Jan;97(1):85-95. [Content Brief]
