533876-30-1
Chemical Structure
SW063058
- CAS No.: 533876-30-1
- Formula:C22H15BrFIN2O2
- Molecular Weight:565.17
IUPAC Name: 7-bromo-5-(4-fluorophenyl)-4-(2-iodobenzoyl)-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one
InChIKey: CFXZDEOFOAXVPQ-UHFFFAOYSA-N
SMILES: O=C1NC2=CC=C(C=C2C(N(C1)C(C3=C(I)C=CC=C3)=O)C4=CC=C(C=C4)F)Br
Biological Activity: SW063058 is an autophagy inducer that specifically disrupts the binding of Beclin 1 to Bcl-2 while leaving the interaction between Bcl-2 and pro-apoptotic members like Bax and BIM unaffected. By inhibiting the negative regulatory effects of Bcl-2 on Beclin 1, which is crucial for the initiation of autophagy, SW063058 promotes autophagic activity without triggering cytotoxicity, apoptosis, or other forms of cell death in vitro.
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SW063058 | SW063058 is an autophagy inducer that specifically disrupts the binding of Beclin 1 to Bcl-2 while leaving the interaction between Bcl-2 and pro-apoptotic members like Bax and BIM unaffected. By inhibiting the negative regulatory effects of Bcl-2 on Beclin 1, which is crucial for the initiation of autophagy, SW063058 promotes autophagic activity without triggering cytotoxicity, apoptosis, or other forms of cell death in vitro. | |||||||||||||||||||||
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Keywords
