5351-17-7
5351-17-7
Chemical Structure
4-Aminobenzohydrazide
Synonym(s): p-Aminobenzohydrazide; p-Aminobenzoic acid hydrazide
- CAS. Nr.: 5351-17-7
- Formula:C7H9N3O
- Molecular Weight:151.17
IUPAC Name: 4-aminobenzohydrazide
InChIKey: WPBZMCGPFHZRHJ-UHFFFAOYSA-N
SMILES: O=C(NN)C1=CC=C(N)C=C1
Biological Activity: 4-Aminobenzohydrazide (p-Aminobenzohydrazide) is an irreversible myeloperoxidase (MPO) inhibitor (IC50=0.3 μM) that induces oxidative stress burst in neutrophils (ROS IC50=43.6 μM). 4-Aminobenzohydrazide has been used in subacute stroke research[1][2][3].
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4-Aminobenzohydrazide | 99.21% | 4-Aminobenzohydrazide (p-Aminobenzohydrazide) is an irreversible myeloperoxidase (MPO) inhibitor (IC50=0.3 μM) that induces oxidative stress burst in neutrophils (ROS IC50=43.6 μM). 4-Aminobenzohydrazide has been used in subacute stroke research. | ||||||||||||||||||||
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4-Aminobenzohydrazide (Standard) | ≥98% | 4-Aminobenzohydrazide (Standard) is the analytical standard of 4-Aminobenzohydrazide. This product is intended for research and analytical applications. 4-Aminobenzohydrazide (p-Aminobenzohydrazide) is an irreversible myeloperoxidase (MPO) inhibitor (IC50=0.3 μM) that induces oxidative stress burst in neutrophils (ROS IC50=43.6 μM). 4-Aminobenzohydrazide has been used in subacute stroke research. | ||||||||||||||||||||
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References
- [1]. Kettle AJ, et al. Inhibition of myeloperoxidase by benzoic acid hydrazides. Biochem J. 1995 Jun 1;308 ( Pt 2)(Pt 2):559-63. [Content Brief]
- [2]. Forghani R, et al. Myeloperoxidase propagates damage and is a potential therapeutic target for subacute stroke. J Cereb Blood Flow Metab. 2015 Mar;35(3):485-93. [Content Brief]
- [3]. Ribeiro D, et al. Modulation of human neutrophils' oxidative burst by flavonoids. Eur J Med Chem. 2013 Sep;67:280-92. [Content Brief]
