55623-37-5
55623-37-5
Chemical Structure
Oxaline
- CAS No.: 55623-37-5
- Formula:C24H25N5O4
- Molecular Weight:447.49
IUPAC Name: (7aR,12aS,E)-3-((1H-imidazol-5-yl)methylene)-6,12-dimethoxy-7a-(2-methylbut-3-en-2-yl)-7a,12-dihydro-1H,5H-imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3H)-dione
InChIKey: SOHAVULMGIITDH-ZXPSTKSJSA-N
SMILES: O=C1N[C@@]23N(OC)C4=C(C=CC=C4)[C@]2(C(C)(C)C=C)C=C(OC)C(N3/C1=C/C5=CN=CN5)=O
Biological Activity: Oxaline is a fungal alkaloid that can be isolated from Penicillium oxalicum. Oxaline inhibits tubulin polymerization, resulting in cell cycle arrest at the M phase[1][2].
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Oxaline | Oxaline is a fungal alkaloid that can be isolated from Penicillium oxalicum. Oxaline inhibits tubulin polymerization, resulting in cell cycle arrest at the M phase. | |||||||||||||||||||||
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References
- [1]. Nagel D W, et al. X-Ray structure of oxaline: a novel alkaloid from Penicillium oxalicum. Journal of the Chemical Society. Chemical Communications. 1974 (24): 1021-1022.
- [2]. Koizumi Y, et al. Oxaline, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of tubulin polymerization. Biochim Biophys Acta. 2004 Jul 23;1693(1):47-55. [Content Brief]
Keywords
