566161-24-8
Chemical Structure
BMS-566419
- CAS No.: 566161-24-8
- Formula:C28H30FN5O2
- Molecular Weight:487.57
IUPAC Name: N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide
InChIKey: XEVJUIZOZCFECP-UHFFFAOYSA-N
SMILES: O=C1C2=CC(F)=C(C(NC(C)(C3=CN=C(N4CCN(CC)CC4)C=C3)C)=O)C=C2NC5=CC=CC=C15
Biological Activity: BMS-566419 is an orally active IMPDH inhibitor with an IC50 of 91 nM against human IMPDH I and 68 nM against human IMPDH II. BMS-566419 exerts anti-heart transplant rejection and anti-renal fibrosis effects, and inhibits the expression of MCP-1, TGF-β1 as well as antibody production. BMS-566419 can be used in research on renal fibrosis and organ transplantation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
BMS-566419 | 99.56% | BMS-566419 is an orally active IMPDH inhibitor with an IC50 of 91 nM against human IMPDH I and 68 nM against human IMPDH II. BMS-566419 exerts anti-heart transplant rejection and anti-renal fibrosis effects, and inhibits the expression of MCP-1, TGF-β1 as well as antibody production. BMS-566419 can be used in research on renal fibrosis and organ transplantation. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.52
HY-17663KMR-206 -
Similarity Score 0.51
HY-14115Hedgehog IN-10 -
Similarity Score 0.51
HY-156922NPY-5 receptor antagonist-1 -
Similarity Score 0.50
HY-153588HSP90-IN-22 -
Similarity Score 0.50
HY-115909ZDLD20 -
Similarity Score 0.50
HY-12856GSK503 -
Similarity Score 0.49
HY-160417PARP1-IN-19 -
Similarity Score 0.49
HY-145584ANesuparib hydrochloride -
Similarity Score 0.49
HY-145584Nesuparib -
Explore the MedChemAI to find more analogs
References
- [1]. Nakanishi T, et al. Effect of the inosine 5'-monophosphate dehydrogenase inhibitor BMS-566419 on rat cardiac allograft rejection. Int Immunopharmacol. 2010;10(1):91-97. [Content Brief]
- [2]. Nakanishi T, et al. Effect of the inosine 5'-monophosphate dehydrogenase inhibitor BMS-566419 on renal fibrosis in unilateral ureteral obstruction in rats. Int Immunopharmacol. 2010;10(11):1434-1439. [Content Brief]
