56632-39-4
56632-39-4
Chemical Structure
BHPI
- CAS No.: 56632-39-4
- Formula:C21H17NO3
- Molecular Weight:331.36
IUPAC Name: 3,3-bis(4-hydroxyphenyl)-7-methylindolin-2-one
InChIKey: FABLAHMQSQFDHR-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C=CC=C2C)C1(C3=CC=C(O)C=C3)C4=CC=C(O)C=C4
Biological Activity: BHPI is a nuclear receptor ERα inhibitor. BHPI activates PLCγ and UPR. BHPI has antitumor activity against breast, endometrial, and ovarian cancers[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BHPI | 98.0% | BHPI is a nuclear receptor ERα inhibitor. BHPI activates PLCγ and UPR. BHPI has antitumor activity against breast, endometrial, and ovarian cancers. | ||||||||||||||||||||
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References
- [1]. Andruska ND, et al. Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4737-42. [Content Brief]
- [2]. Mao C, et al. Antiestrogen Resistant Cell Lines Expressing Estrogen Receptor α Mutations Upregulate the Unfolded Protein Response and are Killed by BHPI. Sci Rep. 2016 Oct 7;6:34753. [Content Brief]
