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Cat. No.: HY-132247A

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(±)-ErSO

Name: (±)-ErSO
Brand: MedChemExpress
SKU: HY-132247A
Price: 350.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(±)-ErSO is the racemate of ErSO. ErSO is a selective anticipatory unfolded protein response (a-UPR) activator.

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CAS No.: 2407860-40-4
Formule: C₂₂H₁₃F₆NO₃
Masse moléculaire:453.33

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

(±)-ErSO Chemical Structure

CAS No.: 2407860-40-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

(±)-ErSO is the racemate of ErSO. ErSO is a selective anticipatory unfolded protein response (a-UPR) activator^[1].

Voir tous les produits spécifiques à Isoform Estrogen Receptor/ERR :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.093 μM Compound: 1	Anticancer activity against ERalpha negative human HCT-116 cells assessed as cell growth inhibition incubated for 168 hrs by alamar blue assay Anticancer activity against ERalpha negative human HCT-116 cells assessed as cell growth inhibition incubated for 168 hrs by alamar blue assay	[PMID: 35080871]
HCT-116	IC₅₀	0.26 μM Compound: 1	Anticancer activity against ERalpha negative human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay Anticancer activity against ERalpha negative human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay	[PMID: 35080871]
HCT-116	IC₅₀	11 μM Compound: 1	Anticancer activity against ERalpha negative human HCT-116 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay Anticancer activity against ERalpha negative human HCT-116 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay	[PMID: 35080871]
HT-29	IC₅₀	0.21 μM Compound: 1	Anticancer activity against ERalpha negative human HT-29 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay Anticancer activity against ERalpha negative human HT-29 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay	[PMID: 35080871]
HT-29	IC₅₀	0.25 μM Compound: 1	Anticancer activity against ERalpha negative human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay Anticancer activity against ERalpha negative human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay	[PMID: 35080871]
MCF7	IC₅₀	0.014 μM Compound: 1	Anticancer activity against ERalpha positive human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay Anticancer activity against ERalpha positive human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay	[PMID: 35080871]
MCF7	IC₅₀	0.02 μM Compound: 1	Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay	[PMID: 35080871]
MDA-MB-231	IC₅₀	23 μM Compound: 1	Anticancer activity against ERalpha negative human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay Anticancer activity against ERalpha negative human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay	[PMID: 35080871]
MDA-MB-231	IC₅₀	6 μM Compound: 1	Anticancer activity against ERalpha negative human MDA-MB-231 cells assessed as cell growth inhibition incubated for 168 hrs by alamar blue assay Anticancer activity against ERalpha negative human MDA-MB-231 cells assessed as cell growth inhibition incubated for 168 hrs by alamar blue assay	[PMID: 35080871]
MDA-MB-231	IC₅₀	8 μM Compound: 1	Anticancer activity against ERalpha negative human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay Anticancer activity against ERalpha negative human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay	[PMID: 35080871]
MDA-MB-436	IC₅₀	14 μM Compound: 1	Anticancer activity against ERalpha negative human MDA-MB-436 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay Anticancer activity against ERalpha negative human MDA-MB-436 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay	[PMID: 35080871]
MDA-MB-436	IC₅₀	22 μM Compound: 1	Anticancer activity against ERalpha negative human MDA-MB-436 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay Anticancer activity against ERalpha negative human MDA-MB-436 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay	[PMID: 35080871]
T47D	IC₅₀	0.01 μM Compound: 1	Anticancer activity against human T47D cells harbouring ERalphaY537S mutant assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay Anticancer activity against human T47D cells harbouring ERalphaY537S mutant assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay	[PMID: 35080871]
T47D	IC₅₀	0.015 μM Compound: 1	Anticancer activity against human T47D cells harbouring ERalphaD538G mutant assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay Anticancer activity against human T47D cells harbouring ERalphaD538G mutant assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay	[PMID: 35080871]
T47D	IC₅₀	0.02 μM Compound: 1	Anticancer activity against ERalpha positive human T47D cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay Anticancer activity against ERalpha positive human T47D cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay	[PMID: 35080871]

Chemical Information

CAS No. 2407860-40-4
Appearance Solid
Masse moléculaire 453.33
Formule C₂₂H₁₃F₆NO₃
Color Light yellow to orange
SMILES

O=C1NC2=C(C=CC=C2C(F)(F)F)C1(C3=CC=C(O)C=C3)C4=CC=C(OC(F)(F)F)C=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Boudreau MW, et al. A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice. Sci Transl Med. 2021;13(603):eabf1383. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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