(±)-ErSO

ADC Targets in Oncology

2026-04-10

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.093 μM Compound: 1	Anticancer activity against ERalpha negative human HCT-116 cells assessed as cell growth inhibition incubated for 168 hrs by alamar blue assay Anticancer activity against ERalpha negative human HCT-116 cells assessed as cell growth inhibition incubated for 168 hrs by alamar blue assay	[PMID: 35080871]
HCT-116	IC₅₀	0.26 μM Compound: 1	Anticancer activity against ERalpha negative human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay Anticancer activity against ERalpha negative human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay	[PMID: 35080871]
HCT-116	IC₅₀	11 μM Compound: 1	Anticancer activity against ERalpha negative human HCT-116 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay Anticancer activity against ERalpha negative human HCT-116 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay	[PMID: 35080871]
HT-29	IC₅₀	0.21 μM Compound: 1	Anticancer activity against ERalpha negative human HT-29 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay Anticancer activity against ERalpha negative human HT-29 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay	[PMID: 35080871]
HT-29	IC₅₀	0.25 μM Compound: 1	Anticancer activity against ERalpha negative human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay Anticancer activity against ERalpha negative human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay	[PMID: 35080871]
MCF7	IC₅₀	0.014 μM Compound: 1	Anticancer activity against ERalpha positive human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay Anticancer activity against ERalpha positive human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay	[PMID: 35080871]
MCF7	IC₅₀	0.02 μM Compound: 1	Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay	[PMID: 35080871]
MDA-MB-231	IC₅₀	23 μM Compound: 1	Anticancer activity against ERalpha negative human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay Anticancer activity against ERalpha negative human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay	[PMID: 35080871]
MDA-MB-231	IC₅₀	6 μM Compound: 1	Anticancer activity against ERalpha negative human MDA-MB-231 cells assessed as cell growth inhibition incubated for 168 hrs by alamar blue assay Anticancer activity against ERalpha negative human MDA-MB-231 cells assessed as cell growth inhibition incubated for 168 hrs by alamar blue assay	[PMID: 35080871]
MDA-MB-231	IC₅₀	8 μM Compound: 1	Anticancer activity against ERalpha negative human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay Anticancer activity against ERalpha negative human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay	[PMID: 35080871]
MDA-MB-436	IC₅₀	14 μM Compound: 1	Anticancer activity against ERalpha negative human MDA-MB-436 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay Anticancer activity against ERalpha negative human MDA-MB-436 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay	[PMID: 35080871]
MDA-MB-436	IC₅₀	22 μM Compound: 1	Anticancer activity against ERalpha negative human MDA-MB-436 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay Anticancer activity against ERalpha negative human MDA-MB-436 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay	[PMID: 35080871]
T47D	IC₅₀	0.01 μM Compound: 1	Anticancer activity against human T47D cells harbouring ERalphaY537S mutant assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay Anticancer activity against human T47D cells harbouring ERalphaY537S mutant assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay	[PMID: 35080871]
T47D	IC₅₀	0.015 μM Compound: 1	Anticancer activity against human T47D cells harbouring ERalphaD538G mutant assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay Anticancer activity against human T47D cells harbouring ERalphaD538G mutant assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay	[PMID: 35080871]
T47D	IC₅₀	0.02 μM Compound: 1	Anticancer activity against ERalpha positive human T47D cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay Anticancer activity against ERalpha positive human T47D cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay	[PMID: 35080871]

Cell Line

Type

Value

Description

References

HCT-116

IC₅₀

0.093 μM

Compound: 1

Anticancer activity against ERalpha negative human HCT-116 cells assessed as cell growth inhibition incubated for 168 hrs by alamar blue assay

[PMID: 35080871]

HCT-116

IC₅₀

0.26 μM

Compound: 1

Anticancer activity against ERalpha negative human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay

[PMID: 35080871]

HCT-116

IC₅₀

11 μM

Compound: 1

Anticancer activity against ERalpha negative human HCT-116 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay

[PMID: 35080871]

HT-29

IC₅₀

0.21 μM

Compound: 1

Anticancer activity against ERalpha negative human HT-29 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay

[PMID: 35080871]

HT-29

IC₅₀

0.25 μM

Compound: 1

Anticancer activity against ERalpha negative human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay

[PMID: 35080871]

MCF7

IC₅₀

0.014 μM

Compound: 1

Anticancer activity against ERalpha positive human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay

[PMID: 35080871]

MCF7

IC₅₀

0.02 μM

Compound: 1

Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay

[PMID: 35080871]

MDA-MB-231

IC₅₀

23 μM

Compound: 1

Anticancer activity against ERalpha negative human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay

[PMID: 35080871]

MDA-MB-231

IC₅₀

6 μM

Compound: 1

Anticancer activity against ERalpha negative human MDA-MB-231 cells assessed as cell growth inhibition incubated for 168 hrs by alamar blue assay

[PMID: 35080871]

MDA-MB-231

IC₅₀

8 μM

Compound: 1

Anticancer activity against ERalpha negative human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay

[PMID: 35080871]

MDA-MB-436

IC₅₀

14 μM

Compound: 1

Anticancer activity against ERalpha negative human MDA-MB-436 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue assay

[PMID: 35080871]

MDA-MB-436

IC₅₀

22 μM

Compound: 1

Anticancer activity against ERalpha negative human MDA-MB-436 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay

[PMID: 35080871]

T47D

IC₅₀

0.01 μM

Compound: 1

Anticancer activity against human T47D cells harbouring ERalphaY537S mutant assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay

[PMID: 35080871]

T47D

IC₅₀

0.015 μM

Compound: 1

Anticancer activity against human T47D cells harbouring ERalphaD538G mutant assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay

[PMID: 35080871]

T47D

IC₅₀

0.02 μM

Compound: 1

Anticancer activity against ERalpha positive human T47D cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay

[PMID: 35080871]

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(±)-ErSO

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(±)-ErSO Related Classifications

Cat. No.: HY-132247A