5728-52-9
5728-52-9
Chemical Structure
Felbinac
Synonym(s): 4-Biphenylacetic acid
- CAS 番号: 5728-52-9
- Formula:C14H12O2
- Molecular Weight:212.25
IUPAC Name: 2-([1,1'-biphenyl]-4-yl)acetic acid
InChIKey: QRZAKQDHEVVFRX-UHFFFAOYSA-N
SMILES: O=C(O)CC1=CC=C(C2=CC=CC=C2)C=C1
Biological Activity: Felbinac is a metabolite of fenbufen, an orally active nonsteroidal anti-inflammatory agent and a cyclooxygenase (COX) inhibitor with an IC50 of 865.68 nM for COX1 and 976 nM for COX2. Felbinac reduces the production of prostaglandins by inhibiting COX to relieve pain, reduce inflammation and reduce fever. Felbinac can inhibit CHIKV viral activity[2][3][4].
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Felbinac | 99.94% | Felbinac is a metabolite of fenbufen, an orally active nonsteroidal anti-inflammatory agent and a cyclooxygenase (COX) inhibitor with an IC50 of 865.68 nM for COX1 and 976 nM for COX2. Felbinac reduces the production of prostaglandins by inhibiting COX to relieve pain, reduce inflammation and reduce fever. Felbinac can inhibit CHIKV viral activity. | ||||||||||||||||||||
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Felbinac (Standard) | ≥98% | Felbinac (Standard) is the analytical standard of Felbinac. This product is intended for research and analytical applications. Felbinac is a potent non-steroidal anti-inflammatory agent, used to treat muscle inflammation and arthritis. | ||||||||||||||||||||
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References
- [2]. Bhagyashri Kasabe, et al. Drug repurposing approach against chikungunya virus: an in vitro and in silico study. Front Cell Infect Microbiol. 2023 Apr 27:13:1132538. [Content Brief]
- [3]. Fumiyo Kasuya, et al. Effect of enoxacin, felbinac, and sparfloxacin on fatty acid metabolism and glucose concentrations in rat tissues. Int J Toxicol. 2011 May;30(3):367-76. [Content Brief]
- [4]. Shah Alam Khan, et al. Synthesis, molecular docking with COX 1& II enzyme, ADMET screening and in vivo anti-inflammatory activity of oxadiazole, thiadiazole and triazole analogs of felbinac.Journal of Saudi Chemical Society. Volume 22, Issue 4
