57568-80-6
57568-80-6
Chemical Structure
PNU 37883 hydrochloride
Synonym(s): PNU 37883A
- CAS No.: 57568-80-6
- Formula:C21H36ClN3O
- Molecular Weight:381.98
IUPAC Name: (Z)-N'-(adamantan-1-yl)-N-cyclohexylmorpholine-4-carboximidamide hydrochloride
InChIKey: FZALCKUJYZCDOX-UHFFFAOYSA-N
SMILES: [H]Cl.N1(/C(NC2CCCCC2)=N\C3(C4)CC5CC4CC(C5)C3)CCOCC1
Biological Activity: PNU 37883 hydrochloride (PNU 37883A) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker. PNU 37883 hydrochloride has diuretic effects with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells[1][2].
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PNU 37883 hydrochloride | 99.66% | PNU 37883 hydrochloride (PNU 37883A) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker. PNU 37883 hydrochloride has diuretic effects with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells. | ||||||||||||||||||||
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References
- [1]. Yi Cui, et al. Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A. Br J Pharmacol. 2003 May;139(1):122-8. [Content Brief]
- [2]. Noriyoshi Teramoto. Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels. Cardiovasc Drug Rev. Spring 2006;24(1):25-32. [Content Brief]
Keywords
