57568-80-6
57568-80-6
Chemical Structure
PNU 37883 hydrochloride
Synonym(s): PNU 37883A
- CAS No.: 57568-80-6
- Formula:C21H36ClN3O
- Molecular Weight:381.98
IUPAC Name: (Z)-N'-(adamantan-1-yl)-N-cyclohexylmorpholine-4-carboximidamide hydrochloride
InChIKey: FZALCKUJYZCDOX-UHFFFAOYSA-N
SMILES: [H]Cl.N1(/C(NC2CCCCC2)=N\C3(C4)CC5CC4CC(C5)C3)CCOCC1
Biological Activity: PNU 37883 hydrochloride (PNU 37883A) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker. PNU 37883 hydrochloride has diuretic effects with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells[1][2].
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PNU 37883 hydrochloride | 99.85% | PNU 37883 hydrochloride (PNU 37883A) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker. PNU 37883 hydrochloride has diuretic effects with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.58
HY-111151RAR-9281 (Standard) -
Similarity Score 0.53
HY-139424SQ609 -
Similarity Score 0.49
HY-W3388561-Adamantylthiourea -
Similarity Score 0.49
HY-W140270R(2b,3a,5a,16b,17b)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol (Standard) -
Similarity Score 0.48
HY-1147471-(Adamantan-1-yl)-3-propylthiourea -
Similarity Score 0.48
HY-U00124BTromantadine hydrochloride -
Similarity Score 0.48
HY-138573N-Acetyl Adamantamine -
Similarity Score 0.48
HY-116561Adamantylmethamphetamine hydrochloride -
Similarity Score 0.48
HY-1679191-(1-Adamantyl)-3-butyl-2-thiourea -
Explore the MedChemAI to find more analogs
References
- [1]. Yi Cui, et al. Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A. Br J Pharmacol. 2003 May;139(1):122-8. [Content Brief]
- [2]. Noriyoshi Teramoto. Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels. Cardiovasc Drug Rev. Spring 2006;24(1):25-32. [Content Brief]
