5796-17-8
Chemical Structure
D-Dopa
Synonym(s): 3-Hydroxy-D-tyrosine
- CAS No.: 5796-17-8
- Formula:C9H11NO4
- Molecular Weight:197.19
IUPAC Name: (R)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
InChIKey: WTDRDQBEARUVNC-ZCFIWIBFSA-N
SMILES: OC([C@H](N)CC1=CC(O)=C(C=C1)O)=O
Biological Activity: D-Dopa (3-Hydroxy-D-tyrosine) is a potent, orally active, non-competitive and allosteric inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 200 nM. D-Dopa elevates brain dopamine and produce turning behavior in rats. D-Dopa inhibit severe fever with thrombocytopenia syndrome (SFTS) virus infection. D-Dopa can be used for neurological disease and virus infection research[1][2][3].
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D-Dopa | 99.67% | D-Dopa (3-Hydroxy-D-tyrosine) is a potent, orally active, non-competitive and allosteric inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 200 nM. D-Dopa elevates brain dopamine and produce turning behavior in rats. D-Dopa inhibit severe fever with thrombocytopenia syndrome (SFTS) virus infection. D-Dopa can be used for neurological disease and virus infection research. | ||||||||||||||||||||
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- [1]. Gori SS, et al., D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II. Pharmaceutics. 2022 Sep 23;14(10):2018. [Content Brief]
- [2]. Karoum F, et al. D-dopa and L-dopa similarly elevate brain dopamine and produce turning behavior in rats. Brain Res. 1988 Feb 2;440(1):190-4. [Content Brief]
- [3]. Ogawa M, et al. L-DOPA, a treatment for Parkinson's disease, and its enantiomer D-DOPA inhibit severe fever with thrombocytopenia syndrome virus infection in vitro. J Infect Chemother. 2022 Mar;28(3):373-376. [Content Brief]
Keywords
