583840-03-3
583840-03-3
Chemical Structure
Sorafenib N-oxide
- CAS No.: 583840-03-3
- Formula:C21H16ClF3N4O4
- Molecular Weight:480.82
IUPAC Name: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-2-(methylcarbamoyl)pyridine 1-oxide
InChIKey: BQAZCCVUZDIZDC-UHFFFAOYSA-N
SMILES: O=C(C1=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C=C2)=CC=[N+]1[O-])NC
Biological Activity: Sorafenib N-oxide is an active metabolite of sorafenib (HY-10201). Sorafenib N-oxide is a linear-mixed inhibitor of microsomal CYP3A4, with a Ki of 15 μM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sorafenib N-oxide | 99.7% | Sorafenib N-oxide is an active metabolite of sorafenib (HY-10201). Sorafenib N-oxide is a linear-mixed inhibitor of microsomal CYP3A4, with a Ki of 15 μM. | ||||||||||||||||||||
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References
- [1]. Li L, et al. Quantitation of sorafenib and its active metabolite sorafenib N-oxide in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Nov 1;878(29):3033-8. [Content Brief]
- [2]. Ghassabian S, et al. Sorafenib N-Oxide Is an Inhibitor of Human Hepatic CYP3A4. AAPS J. 2019 Jan 9;21(2):15. [Content Brief]
Keywords
